| Reaction Details |
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 | Report a problem with these data |
| Target | Calmodulin-domain protein kinase 1 |
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| Ligand | BDBM50250001 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1680859 |
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| IC50 | 78±n/a nM |
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| Citation |  Rutaganira, FU; Barks, J; Dhason, MS; Wang, Q; Lopez, MS; Long, S; Radke, JB; Jones, NG; Maddirala, AR; Janetka, JW; El Bakkouri, M; Hui, R; Shokat, KM; Sibley, LD Inhibition of Calcium Dependent Protein Kinase 1 (CDPK1) by Pyrazolopyrimidine Analogs Decreases Establishment and Reoccurrence of Central Nervous System Disease by Toxoplasma gondii. J Med Chem60:9976-9989 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Calmodulin-domain protein kinase 1 |
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| Name: | Calmodulin-domain protein kinase 1 |
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| Synonyms: | Calmodulin-domain protein kinase 1 | Calmodulin-domain protein kinase 1 (CDPK1) | Calmodulin-domain protein kinase, putative |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 57248.42 |
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| Organism: | Toxoplasma gondii |
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| Description: | n/a |
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| Residue: | 507 |
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| Sequence: | MGQQESTLGGAAGEPRSRGHAAGTSGGPGDHLHATPGMFVQHSTAIFSDRYKGQRVLGKG
SFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYEFFED
KGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENL
LLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVIL
YILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTYVPSMRISAR
DALDHEWIQTYTKEQISVDVPSLDNAILNIRQFQGTQKLAQAALLYMGSKLTSQDETKEL
TAIFHKMDKNGDGQLDRAELIEGYKELMRMKGQDASMLDASAVEHEVDQVLDAVDFDKNG
YIEYSEFVTVAMDRKTLLSRERLERAFRMFDSDNSGKISSTELATIFGVSDVDSETWKSV
LSEVDKNNDGEVDFDEFQQMLLKLCGN
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| BDBM50250001 |
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| n/a |
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| Name | BDBM50250001 |
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| Synonyms: | CHEMBL4090973 | US11208411, Compound FUR7-30 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H21ClN6O |
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| Mol. Mass. | 372.852 |
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| SMILES | CN1CCC(Cn2nc(Oc3cccc(Cl)c3)c3c(N)ncnc23)CC1 |
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| Structure | 
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