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TargetDual specificity tyrosine-phosphorylation-regulated kinase 3
LigandBDBM317462
Substrate/Competitorn/a
Meas. Tech.ChEBML_1681480
IC50 99±n/a nM
Citation Riggs, JRNagy, MElsner, JErdman, PCashion, DRobinson, DHarris, RHuang, DTehrani, LDeyanat-Yazdi, GNarla, RKPeng, XTran, TBarnes, LMiller, TKatz, JTang, YChen, MMoghaddam, MFBahmanyar, SPagarigan, BDelker, SLeBrun, LChamberlain, PPCalabrese, ACanan, SSLeftheris, KZhu, DBoylan, JF The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen. J Med Chem60:8989-9002 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dual specificity tyrosine-phosphorylation-regulated kinase 3
Name:Dual specificity tyrosine-phosphorylation-regulated kinase 3
Synonyms:DYRK3 | DYRK3_HUMAN | Dual-specificity tyrosine-phosphorylation regulated kinase 3
Type:PROTEIN
Mol. Mass.:65747.26
Organism:Homo sapiens (Human)
Description:ChEMBL_1508026
Residue:588
Sequence:
MGGTARGPGRKDAGPPGAGLPPQQRRLGDGVYDTFMMIDETKCPPCSNVLCNPSEPPPPR
RLNMTTEQFTGDHTQHFLDGGEMKVEQLFQEFGNRKSNTIQSDGISDSEKCSPTVSQGKS
SDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHG
VIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV
RNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIK
KNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC
FEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLAC
MMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGS
KDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKR
VVNPASAFQGLGSKLPPVVGIANKLKANLMSETNGSIPLCSVLPKLIS
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  Blast E-value cutoff:
BDBM317462
n/a
NameBDBM317462
Synonyms:4-(4-(cyclopentyloxy)-5-(2- methylbenzo[d]oxazol-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2- ylamino)-3-methoxy-N- methylbenzamide | US9623028, Compound 38
TypeSmall organic molecule
Emp. Form.C28H28N6O4
Mol. Mass.512.5597
SMILESCNC(=O)c1ccc(Nc2nc(OC3CCCC3)c3c(c[nH]c3n2)-c2ccc3nc(C)oc3c2)c(OC)c1
Structure
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