Reaction Details |
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Target | Dual specificity tyrosine-phosphorylation-regulated kinase 3 |
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Ligand | BDBM317462 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_1681480 |
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IC50 | 99±n/a nM |
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Citation | Riggs, JR; Nagy, M; Elsner, J; Erdman, P; Cashion, D; Robinson, D; Harris, R; Huang, D; Tehrani, L; Deyanat-Yazdi, G; Narla, RK; Peng, X; Tran, T; Barnes, L; Miller, T; Katz, J; Tang, Y; Chen, M; Moghaddam, MF; Bahmanyar, S; Pagarigan, B; Delker, S; LeBrun, L; Chamberlain, PP; Calabrese, A; Canan, SS; Leftheris, K; Zhu, D; Boylan, JF The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen. J Med Chem60:8989-9002 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dual specificity tyrosine-phosphorylation-regulated kinase 3 |
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Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 3 |
Synonyms: | DYRK3 | DYRK3_HUMAN | Dual-specificity tyrosine-phosphorylation regulated kinase 3 |
Type: | PROTEIN |
Mol. Mass.: | 65747.26 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1508026 |
Residue: | 588 |
Sequence: | MGGTARGPGRKDAGPPGAGLPPQQRRLGDGVYDTFMMIDETKCPPCSNVLCNPSEPPPPR
RLNMTTEQFTGDHTQHFLDGGEMKVEQLFQEFGNRKSNTIQSDGISDSEKCSPTVSQGKS
SDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHG
VIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV
RNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIK
KNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC
FEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLAC
MMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGS
KDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKR
VVNPASAFQGLGSKLPPVVGIANKLKANLMSETNGSIPLCSVLPKLIS
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BDBM317462 |
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n/a |
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Name | BDBM317462 |
Synonyms: | 4-(4-(cyclopentyloxy)-5-(2- methylbenzo[d]oxazol-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2- ylamino)-3-methoxy-N- methylbenzamide | US9623028, Compound 38 |
Type | Small organic molecule |
Emp. Form. | C28H28N6O4 |
Mol. Mass. | 512.5597 |
SMILES | CNC(=O)c1ccc(Nc2nc(OC3CCCC3)c3c(c[nH]c3n2)-c2ccc3nc(C)oc3c2)c(OC)c1 |
Structure |
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