| Reaction Details |
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 | Report a problem with these data |
| Target | Atypical chemokine receptor 3 |
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| Ligand | BDBM50250376 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1681650 (CHEMBL4031927) |
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| Ki | 200±n/a nM |
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| Citation |  Boehm, M; Beaumont, K; Jones, R; Kalgutkar, AS; Zhang, L; Atkinson, K; Bai, G; Brown, JA; Eng, H; Goetz, GH; Holder, BR; Khunte, B; Lazzaro, S; Limberakis, C; Ryu, S; Shapiro, MJ; Tylaska, L; Yan, J; Turner, R; Leung, SSF; Ramaseshan, M; Price, DA; Liras, S; Jacobson, MP; Earp, DJ; Lokey, RS; Mathiowetz, AM; Menhaji-Klotz, E Discovery of Potent and Orally Bioavailable Macrocyclic Peptide-Peptoid Hybrid CXCR7 Modulators. J Med Chem60:9653-9663 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Atypical chemokine receptor 3 |
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| Name: | Atypical chemokine receptor 3 |
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| Synonyms: | ACKR3 | ACKR3_HUMAN | C-X-C chemokine receptor type 7 | C-X-C chemokine receptor type 7 (CXCR7) | CMKOR1 | CXC-R7 | CXCR-7 | CXCR7 | Chemokine orphan receptor 1 | G-protein coupled receptor 159 | G-protein coupled receptor RDC1 homolog | GPR159 | RDC-1 | RDC1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41498.84 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25106 |
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| Residue: | 362 |
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| Sequence: | MDLHLFDYSEPGNFSDISWPCNSSDCIVVDTVMCPNMPNKSVLLYTLSFIYIFIFVIGMI
ANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVT
HLIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDT
YYLKTVTSASNNETYCRSFYPEHSIKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAIS
ASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIPFTCRLEHALFTALHVT
QCLSLVHCCVNPVLYSFINRNYRYELMKAFIFKYSAKTGLTKLIDASRVSETEYSALEQS
TK
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| BDBM50250376 |
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| n/a |
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| Name | BDBM50250376 |
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| Synonyms: | CHEMBL4078800 |
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| Type | Small organic molecule |
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| Emp. Form. | C52H60N8O6S |
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| Mol. Mass. | 925.148 |
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| SMILES | CN1[C@@H](Cc2cscn2)C(=O)N[C@@H](Cc2cccnc2)C(=O)N2CCC[C@@H]2C(=O)N(CCCc2ccccc2)CC(=O)N[C@@H](CCCc2ccccc2)C(=O)N(C)[C@H](Cc2ccccc2)C1=O |r| |
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| Structure | 
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