Reaction Details |
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Target | Muscarinic acetylcholine receptor M1 |
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Ligand | BDBM50005856 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_138958 (CHEMBL742770) |
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Ki | 15900±n/a nM |
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Citation | Garvey, DS; Wasicak, JT; Chung, JY; Shue, YK; Carrera, GM; May, PD; McKinney, MM; Anderson, D; Cadman, E; Vella-Rountree, L Synthesis and in vitro characterization of novel amino terminally modified oxotremorine derivatives for brain muscarinic receptors. J Med Chem35:1550-7 (1992) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Muscarinic acetylcholine receptor M1 |
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Name: | Muscarinic acetylcholine receptor M1 |
Synonyms: | ACM1_RAT | Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 51390.46 |
Organism: | RAT |
Description: | P08482 |
Residue: | 460 |
Sequence: | MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
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BDBM50005856 |
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n/a |
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Name | BDBM50005856 |
Synonyms: | 1-(4-Dimethylamino-but-2-ynyl)-pyrrolidin-2-one | CHEMBL41779 |
Type | Small organic molecule |
Emp. Form. | C10H16N2O |
Mol. Mass. | 180.2468 |
SMILES | CN(C)CC#CCN1CCCC1=O |
Structure |
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