| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PAK 4 |
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| Ligand | BDBM50251177 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1683091 (CHEMBL4033368) |
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| Ki | 114±n/a nM |
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| Citation |  Hao, C; Zhao, F; Song, H; Guo, J; Li, X; Jiang, X; Huan, R; Song, S; Zhang, Q; Wang, R; Wang, K; Pang, Y; Liu, T; Lu, T; Huang, W; Wang, J; Lin, B; He, Z; Li, H; Li, F; Zhao, D; Cheng, M Structure-Based Design of 6-Chloro-4-aminoquinazoline-2-carboxamide Derivatives as Potent and Selective p21-Activated Kinase 4 (PAK4) Inhibitors. J Med Chem61:265-285 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase PAK 4 |
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| Name: | Serine/threonine-protein kinase PAK 4 |
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| Synonyms: | KIAA1142 | PAK4 | PAK4_HUMAN | p21-Activated kinase 4 (PAK4) |
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| Type: | Protein |
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| Mol. Mass.: | 64098.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O96013 |
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| Residue: | 591 |
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| Sequence: | MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT
SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEE
PATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPL
SGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIP
QSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVS
HEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR
ELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAV
CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPY
WMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHK
VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR
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| BDBM50251177 |
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| n/a |
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| Name | BDBM50251177 |
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| Synonyms: | CHEMBL4090268 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H24ClN7O |
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| Mol. Mass. | 425.915 |
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| SMILES | CC1CN(CC(C)N1)C(=O)c1nc(Nc2cc([nH]n2)C2CC2)c2cc(Cl)ccc2n1 |
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| Structure | 
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