| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M3 |
|---|
| Ligand | BDBM50453186 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_138852 |
|---|
| Ki | 8.3±n/a nM |
|---|
| Citation |  Carroll, FI; Abraham, P; Chemburkar, S; He, XC; Mascarella, SW; Kwon, YW; Triggle, DJ Synthesis and muscarinic receptor activity of ester derivatives of 2-substituted 2-azabicyclo[2.2.1]heptan-5-ol and -6-ol. J Med Chem35:2184-91 (1992) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Muscarinic acetylcholine receptor M3 |
|---|
| Name: | Muscarinic acetylcholine receptor M3 |
|---|
| Synonyms: | ACM3_RAT | Cholinergic, muscarinic M3 | Chrm-3 | Chrm3 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 66086.66 |
|---|
| Organism: | RAT |
|---|
| Description: | Cholinergic, muscarinic M3 CHRM3 RAT::P08483 |
|---|
| Residue: | 589 |
|---|
| Sequence: | MTLHSNSTTSPLFPNISSSWVHSPSEAGLPLGTVTQLGSYNISQETGNFSSNDTSSDPLG
GHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVIS
MNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRT
TKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFY
MPVTIMTILYWRIYKETEKRTKELAGLQASGTEAEAENFVHPTGSSRSCSSYELQQQGVK
RSSRRKYGRCHFWFTTKSWKPSAEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSET
RAIYSIVLKLPGHSSILNSTKLPSSDNLQVSNEDLGTVDVERNAHKLQAQKSMGDGDNCQ
KDFTKLPIQLESAVDTGKTSDTNSSADKTTATLPLSFKEATLAKRFALKTRSQITKRKRM
SLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNP
VCYALCNKTFRTTFKTLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL
|
|
|
|---|
| BDBM50453186 |
|---|
| n/a |
|---|
| Name | BDBM50453186 |
|---|
| Synonyms: | CHEMBL2115125 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H25NO2 |
|---|
| Mol. Mass. | 335.4394 |
|---|
| SMILES | CN1CC2C[C@@H](OC(=O)C(C)(c3ccccc3)c3ccccc3)C1C2 |r,TLB:6:5:1.2:24,0:1:5.4:24| |
|---|
| Structure | 
|
|---|
Search and Browse
