Ki Summary

Reaction Details

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Target

Muscarinic acetylcholine receptor M1

Ligand

BDBM50003369

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_138796 (CHEMBL752914)

IC50

1.6±n/a nM

Citation

Sauerberg, P; Olesen, PH; Nielsen, S; Treppendahl, S; Sheardown, MJ; Honoré, T; Mitch, CH; Ward, JS; Pike, AJ; Bymaster, FP Novel functional M1 selective muscarinic agonists. Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines . J Med Chem35:2274-83 (1992) [PubMed]

More Info.:

Get all data from this article, Assay Method

Muscarinic acetylcholine receptor M1

Name:

Muscarinic acetylcholine receptor M1

Synonyms:

ACM1_RAT | Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1

Type:

Enzyme Catalytic Domain

Mol. Mass.:

51390.46

Organism:

RAT

Description:

P08482

Residue:

460

Sequence:

MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC

BDBM50003369

n/a

Name

BDBM50003369

Synonyms:

1-Methyl-5-(4-propoxy-[1,2,5]thiadiazol-3-yl)-1,2,3,6-tetrahydro-pyridine | 1-Methyl-5-(4-propoxy-[1,2,5]thiadiazol-3-yl)-1,2,3,6-tetrahydro-pyridine; oxalic acid | 1-methyl-5-(4-propoxy-1,2,5-thiadiazol-3-yl)-1,2,3,6-tetrahydropyridine | CHEMBL303922 | CHEMBL308803

Type

Small organic molecule

Emp. Form.

C11H17N3OS

Mol. Mass.

239.337

SMILES

CCCOc1nsnc1C1=CCCN(C)C1 |t:10|

Structure