| Reaction Details |
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 | Report a problem with these data |
| Target | M-phase inducer phosphatase 3 |
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| Ligand | BDBM50251709 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1684263 |
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| IC50 | 4670±n/a nM |
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| Citation |  Zwergel, C; Czepukojc, B; Evain-Bana, E; Xu, Z; Stazi, G; Mori, M; Patsilinakos, A; Mai, A; Botta, B; Ragno, R; Bagrel, D; Kirsch, G; Meiser, P; Jacob, C; Montenarh, M; Valente, S Novel coumarin- and quinolinone-based polycycles as cell division cycle 25-A and -C phosphatases inhibitors induce proliferation arrest and apoptosis in cancer cells. Eur J Med Chem134:316-333 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| M-phase inducer phosphatase 3 |
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| Name: | M-phase inducer phosphatase 3 |
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| Synonyms: | CDC25C | Dual specificity phosphatase Cdc25C | M-phase inducer phosphatase 3 | MPIP3_HUMAN |
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| Type: | Substrate |
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| Mol. Mass.: | 53366.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30307 |
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| Residue: | 473 |
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| Sequence: | MSTELFSSTREEGSSGSGPSFRSNQRKMLNLLLERDTSFTVCPDVPRTPVGKFLGDSANL
SILSGGTPKRCLDLSNLSSGEITATQLTTSADLDETGHLDSSGLQEVHLAGMNHDQHLMK
CSPAQLLCSTPNGLDRGHRKRDAMCSSSANKENDNGNLVDSEMKYLGSPITTVPKLDKNP
NLGEDQAEEISDELMEFSLKDQEAKVSRSGLYRSPSMPENLNRPRLKQVEKFKDNTIPDK
VKKKYFSGQGKLRKGLCLKKTVSLCDITITQMLEEDSNQGHLIGDFSKVCALPTVSGKHQ
DLKYVNPETVAALLSGKFQGLIEKFYVIDCRYPYEYLGGHIQGALNLYSQEELFNFFLKK
PIVPLDTQKRIIIVFHCEFSSERGPRMCRCLREEDRSLNQYPALYYPELYILKGGYRDFF
PEYMELCEPQSYCPMHHQDHKTELLRCRSQSKVQEGERQLREQIALLVKDMSP
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| BDBM50251709 |
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| n/a |
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| Name | BDBM50251709 |
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| Synonyms: | CHEMBL4094844 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H8FNO3 |
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| Mol. Mass. | 293.2487 |
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| SMILES | Fc1ccc2[nH]c(=O)c3c4C(=O)C=CC(=O)c4ccc3c2c1 |c:12| |
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| Structure | 
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