| Reaction Details |
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 | Report a problem with these data |
| Target | M-phase inducer phosphatase 1 |
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| Ligand | BDBM50251724 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1684262 |
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| IC50 | 1200±n/a nM |
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| Citation |  Zwergel, C; Czepukojc, B; Evain-Bana, E; Xu, Z; Stazi, G; Mori, M; Patsilinakos, A; Mai, A; Botta, B; Ragno, R; Bagrel, D; Kirsch, G; Meiser, P; Jacob, C; Montenarh, M; Valente, S Novel coumarin- and quinolinone-based polycycles as cell division cycle 25-A and -C phosphatases inhibitors induce proliferation arrest and apoptosis in cancer cells. Eur J Med Chem134:316-333 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| M-phase inducer phosphatase 1 |
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| Name: | M-phase inducer phosphatase 1 |
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| Synonyms: | CDC25A | Dual specificity phosphatase (Cdc25A) | Dual specificity phosphatase Cdc25A | M-phase inducer phosphatase 1 | MPIP1_HUMAN | phosphatase Cdc25 |
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| Type: | Protein |
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| Mol. Mass.: | 59090.18 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30304 |
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| Residue: | 524 |
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| Sequence: | MELGPEPPHRRRLLFACSPPPASQPVVKALFGASAAGGLSPVTNLTVTMDQLQGLGSDYE
QPLEVKNNSNLQRMGSSESTDSGFCLDSPGPLDSKENLENPMRRIHSLPQKLLGCSPALK
RSHSDSLDHDIFQLIDPDENKENEAFEFKKPVRPVSRGCLHSHGLQEGKDLFTQRQNSAP
ARMLSSNERDSSEPGNFIPLFTPQSPVTATLSDEDDGFVDLLDGENLKNEEETPSCMASL
WTAPLVMRTTNLDNRCKLFDSPSLCSSSTRSVLKRPERSQEESPPGSTKRRKSMSGASPK
ESTNPEKAHETLHQSLSLASSPKGTIENILDNDPRDLIGDFSKGYLFHTVAGKHQDLKYI
SPEIMASVLNGKFANLIKEFVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKKPIVPT
DGKRVIVVFHCEFSSERGPRMCRYVRERDRLGNEYPKLHYPELYVLKGGYKEFFMKCQSY
CEPPSYRPMHHEDFKEDLKKFRTKSRTWAGEKSKREMYSRLKKL
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| BDBM50251724 |
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| n/a |
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| Name | BDBM50251724 |
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| Synonyms: | CHEMBL4066424 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H17NO4 |
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| Mol. Mass. | 347.364 |
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| SMILES | CCN(CC)c1ccc2c(c1)oc(=O)c1c3C(=O)C=CC(=O)c3ccc21 |c:19| |
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| Structure | 
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