| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidylate synthase |
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| Ligand | BDBM50006905 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_209976 |
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| Ki | 28000±n/a nM |
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| Citation |  Rosowsky, A; Forsch, RA; Moran, RG N-[4-[[(3,4-dihydro-4-oxo-1,2,3-benzotriazin-6- yl)methyl]amino]benzoyl]-L-glutamic acid, a novel A-ring analogue of 2-desamino-5,8-dideazafolic acid. J Med Chem35:2626-30 (1992) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidylate synthase |
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| Name: | Thymidylate synthase |
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| Synonyms: | TS | TSase | TYSY_MOUSE | Tyms |
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| Type: | PROTEIN |
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| Mol. Mass.: | 34957.15 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1340097 |
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| Residue: | 307 |
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| Sequence: | MLVVGSELQSDAQQLSAEAPRHGELQYLRQVEHILRCGFKKEDRTGTGTLSVFGMQARYS
LRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSAR
QEGDLGPVYGFQWRHFGAEYKDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKD
LPLMALPPCHALCQFYVVNGELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLQPG
DFVHTLGDAHIYLNHIEPLKIQLQREPRPFPKLKILRKVETIDDFKVEDFQIEGYNPHPT
IKMEMAV
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| BDBM50006905 |
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| n/a |
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| Name | BDBM50006905 |
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| Synonyms: | 2-{4-[(4-Oxo-3,4-dihydro-benzo[d][1,2,3]triazin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid | CHEMBL316019 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19N5O6 |
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| Mol. Mass. | 425.3948 |
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| SMILES | OC(=O)CCC(NC(=O)c1ccc(NCc2ccc3nn[nH]c(=O)c3c2)cc1)C(O)=O |
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| Structure | 
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