Reaction Details |
| Report a problem with these data |
Target | Cytosolic endo-beta-N-acetylglucosaminidase |
---|
Ligand | BDBM50070208 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEBML_1685304 |
---|
IC50 | 24380±n/a nM |
---|
Citation | Bi, Y; Might, M; Vankayalapati, H; Kuberan, B Repurposing of Proton Pump Inhibitors as first identified small molecule inhibitors of endo-?-N-acetylglucosaminidase (ENGase) for the treatment of NGLY1 deficiency, a rare genetic disease. Bioorg Med Chem Lett27:2962-2966 (2017) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Cytosolic endo-beta-N-acetylglucosaminidase |
---|
Name: | Cytosolic endo-beta-N-acetylglucosaminidase |
Synonyms: | ENASE_HUMAN | ENGASE | Endo-beta-N-acetylglucosaminidase |
Type: | PROTEIN |
Mol. Mass.: | 83989.32 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_467019 |
Residue: | 743 |
Sequence: | MEAAAVTVTRSATRRRRRQLQGLAAPEAGTQEEQEDQEPRPRRRRPGRSIKDEEEETVFR
EVVSFSPDPLPVRYYDKDTTKPISFYLSSLEELLAWKPRLEDGFNVALEPLACRQPPLSS
QRPRTLLCHDMMGGYLDDRFIQGSVVQTPYAFYHWQCIDVFVYFSHHTVTIPPVGWTNTA
HRHGVCVLGTFITEWNEGGRLCEAFLAGDERSYQAVADRLVQITQFFRFDGWLINIENSL
SLAAVGNMPPFLRYLTTQLHRQVPGGLVLWYDSVVQSGQLKWQDELNQHNRVFFDSCDGF
FTNYNWREEHLERMLGQAGERRADVYVGVDVFARGNVVGGRFDTDKSLELIRKHGFSVAL
FAPGWVYECLEKKDFFQNQDKFWGRLERYLPTHSICSLPFVTSFCLGMGARRVCYGQEEA
VGPWYHLSAQEIQPLFGEHRLGGDGRGWVRTHCCLEDAWHGGSSLLVRGVIPPEVGNVAV
RLFSLQAPVPPKIYLSMVYKLEGPTDVTVALELTTGDAGSCHIGGISVLNAETSSRHSLR
PLRVPPTKLARWVGRCGRQLSGGWVQHCYEVSLRGCLLLDLLVCFSRPPGSREEESFTCR
LGEIQVVDAASLLAPLPQVQAVTISHIRWQPSASEREGPPALLQLSCTLHWSFLLSQVRC
FRIHCWGGMSDDSPGRELPRPEMPMFLGLAFATQYRIVDLLVEAAGPGQDRRMEFLVEPV
PKEGFRVPQAEWGRAVLLYSAPA
|
|
|
BDBM50070208 |
---|
n/a |
---|
Name | BDBM50070208 |
Synonyms: | A-65006 | AG-1749 | CHEBI:6375 | Lansoprazole | Prevacid | Prevacid 24hr | Prevacid Delayed Release | Prevacid Solutab | Prevacid iv |
Type | Small organic molecule |
Emp. Form. | C16H14F3N3O2S |
Mol. Mass. | 369.361 |
SMILES | Cc1c(OCC(F)(F)F)ccnc1C[S+]([O-])c1nc2ccccc2[nH]1 |
Structure |
|