Reaction Details | |||
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Target | Potassium voltage-gated channel subfamily H member 2 | ||
Ligand | BDBM50254142 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1686117 (CHEMBL4036596) | ||
IC50 | 24900±n/a nM | ||
Citation | Mitton-Fry, MJ; Brickner, SJ; Hamel, JC; Barham, R; Brennan, L; Casavant, JM; Ding, X; Finegan, S; Hardink, J; Hoang, T; Huband, MD; Maloney, M; Marfat, A; McCurdy, SP; McLeod, D; Subramanyam, C; Plotkin, M; Reilly, U; Schafer, J; Stone, GG; Uccello, DP; Wisialowski, T; Yoon, K; Zaniewski, R; Zook, C Novel 3-fluoro-6-methoxyquinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV. Bioorg Med Chem Lett27:3353-3358 (2017) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Potassium voltage-gated channel subfamily H member 2 | |||
Name: | Potassium voltage-gated channel subfamily H member 2 | ||
Synonyms: | 1,3-beta-glucan synthase component GLS2 | Cytochrome P450 3A4 | ERG | ERG1 | Eag-related protein 1 | Ether a-go-go related gene potassium channel (hERG) | Ether-a-go-go-related gene (HERG) | Ether-a-go-go-related gene potassium channel (hERG) | Ether-a-go-go-related gene potassium channel 1 | Ether-a-go-go-related gene potassium channel 1 (HERG) | Ether-a-go-go-related gene potassium channel 1 (hERG1) | Ether-a-go-go-related protein (hERG) | Ether-a-go-go-related protein 1 | Ether-a-go-go-related protein 1 (HERG) | H-ERG | HERG | KCNH2 | KCNH2_HUMAN | Potassium voltage-gated channel subfamily H member 2 (hERG) | Transcriptional regulator ERG | Voltage-gated potassium channel subunit Kv11.1 | eag homolog | hERG Potassium Channel 1 | putative potassium channel subunit | ||
Type: | Multi-pass membrane protein | ||
Mol. Mass.: | 126672.65 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q12809 | ||
Residue: | 1159 | ||
Sequence: |
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BDBM50254142 | |||
n/a | |||
Name | BDBM50254142 | ||
Synonyms: | CHEMBL2382287 | ||
Type | Small organic molecule | ||
Emp. Form. | C29H34N2O4 | ||
Mol. Mass. | 474.5913 | ||
SMILES | COc1ccc2nccc([C@@H](O)CC[C@@H]3CCN(C[C@@H]3C(O)=O)C3CC(C3)c3ccccc3)c2c1 |r,wU:10.10,14.13,19.20,(27.36,-12.97,;28.69,-12.2,;30.02,-12.97,;30.02,-14.51,;31.36,-15.28,;32.69,-14.5,;34.03,-15.27,;35.36,-14.5,;35.35,-12.95,;34.01,-12.19,;34.01,-10.65,;32.67,-9.88,;35.34,-9.87,;36.67,-10.63,;38,-9.86,;39.34,-10.63,;40.66,-9.86,;40.66,-8.32,;39.33,-7.55,;37.99,-8.32,;36.65,-7.56,;35.32,-8.34,;36.64,-6.02,;42,-7.54,;43.48,-7.92,;43.88,-6.42,;42.41,-6.04,;45.2,-5.64,;46.54,-6.4,;47.87,-5.63,;47.86,-4.08,;46.51,-3.32,;45.19,-4.11,;32.69,-12.96,;31.35,-12.2,)| | ||
Structure |