Reaction Details | |||
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Target | Potassium voltage-gated channel subfamily H member 2 | ||
Ligand | BDBM50254151 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1686117 (CHEMBL4036596) | ||
IC50 | 22300±n/a nM | ||
Citation | Mitton-Fry, MJ; Brickner, SJ; Hamel, JC; Barham, R; Brennan, L; Casavant, JM; Ding, X; Finegan, S; Hardink, J; Hoang, T; Huband, MD; Maloney, M; Marfat, A; McCurdy, SP; McLeod, D; Subramanyam, C; Plotkin, M; Reilly, U; Schafer, J; Stone, GG; Uccello, DP; Wisialowski, T; Yoon, K; Zaniewski, R; Zook, C Novel 3-fluoro-6-methoxyquinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV. Bioorg Med Chem Lett27:3353-3358 (2017) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Potassium voltage-gated channel subfamily H member 2 | |||
Name: | Potassium voltage-gated channel subfamily H member 2 | ||
Synonyms: | 1,3-beta-glucan synthase component GLS2 | Cytochrome P450 3A4 | ERG | ERG1 | Eag-related protein 1 | Ether a-go-go related gene potassium channel (hERG) | Ether-a-go-go-related gene (HERG) | Ether-a-go-go-related gene potassium channel (hERG) | Ether-a-go-go-related gene potassium channel 1 | Ether-a-go-go-related gene potassium channel 1 (HERG) | Ether-a-go-go-related gene potassium channel 1 (hERG1) | Ether-a-go-go-related protein (hERG) | Ether-a-go-go-related protein 1 | Ether-a-go-go-related protein 1 (HERG) | H-ERG | HERG | KCNH2 | KCNH2_HUMAN | Potassium voltage-gated channel subfamily H member 2 (hERG) | Transcriptional regulator ERG | Voltage-gated potassium channel subunit Kv11.1 | eag homolog | hERG Potassium Channel 1 | putative potassium channel subunit | ||
Type: | Multi-pass membrane protein | ||
Mol. Mass.: | 126672.65 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q12809 | ||
Residue: | 1159 | ||
Sequence: |
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BDBM50254151 | |||
n/a | |||
Name | BDBM50254151 | ||
Synonyms: | CHEMBL4103746 | ||
Type | Small organic molecule | ||
Emp. Form. | C29H33FN2O4 | ||
Mol. Mass. | 492.5817 | ||
SMILES | COc1ccc2ncc(F)c([C@@H](O)CC[C@@H]3CCN(C[C@@H]3C(O)=O)C3CC(C3)c3ccccc3)c2c1 |r,wU:11.11,15.14,20.21,(2.57,-47.52,;3.9,-46.75,;5.23,-47.52,;5.23,-49.07,;6.57,-49.84,;7.9,-49.06,;9.24,-49.83,;10.57,-49.05,;10.57,-47.5,;11.9,-46.73,;9.23,-46.74,;9.22,-45.2,;7.88,-44.44,;10.55,-44.42,;11.89,-45.19,;13.22,-44.41,;14.55,-45.18,;15.88,-44.41,;15.88,-42.87,;14.54,-42.1,;13.21,-42.87,;11.87,-42.11,;10.54,-42.89,;11.86,-40.57,;17.21,-42.1,;18.69,-42.5,;19.09,-41.01,;17.6,-40.62,;20.41,-40.24,;21.75,-41.01,;23.08,-40.24,;23.08,-38.7,;21.74,-37.93,;20.41,-38.71,;7.9,-47.51,;6.56,-46.75,)| | ||
Structure |