Reaction Details | |||
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Target | Potassium voltage-gated channel subfamily H member 2 | ||
Ligand | BDBM50254159 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1686117 (CHEMBL4036596) | ||
IC50 | 25000±n/a nM | ||
Citation | Mitton-Fry, MJ; Brickner, SJ; Hamel, JC; Barham, R; Brennan, L; Casavant, JM; Ding, X; Finegan, S; Hardink, J; Hoang, T; Huband, MD; Maloney, M; Marfat, A; McCurdy, SP; McLeod, D; Subramanyam, C; Plotkin, M; Reilly, U; Schafer, J; Stone, GG; Uccello, DP; Wisialowski, T; Yoon, K; Zaniewski, R; Zook, C Novel 3-fluoro-6-methoxyquinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV. Bioorg Med Chem Lett27:3353-3358 (2017) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Potassium voltage-gated channel subfamily H member 2 | |||
Name: | Potassium voltage-gated channel subfamily H member 2 | ||
Synonyms: | 1,3-beta-glucan synthase component GLS2 | Cytochrome P450 3A4 | ERG | ERG1 | Eag-related protein 1 | Ether a-go-go related gene potassium channel (hERG) | Ether-a-go-go-related gene (HERG) | Ether-a-go-go-related gene potassium channel (hERG) | Ether-a-go-go-related gene potassium channel 1 | Ether-a-go-go-related gene potassium channel 1 (HERG) | Ether-a-go-go-related gene potassium channel 1 (hERG1) | Ether-a-go-go-related protein (hERG) | Ether-a-go-go-related protein 1 | Ether-a-go-go-related protein 1 (HERG) | H-ERG | HERG | KCNH2 | KCNH2_HUMAN | Potassium voltage-gated channel subfamily H member 2 (hERG) | Transcriptional regulator ERG | Voltage-gated potassium channel subunit Kv11.1 | eag homolog | hERG Potassium Channel 1 | putative potassium channel subunit | ||
Type: | Multi-pass membrane protein | ||
Mol. Mass.: | 126672.65 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q12809 | ||
Residue: | 1159 | ||
Sequence: |
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BDBM50254159 | |||
n/a | |||
Name | BDBM50254159 | ||
Synonyms: | CHEMBL4079869 | ||
Type | Small organic molecule | ||
Emp. Form. | C29H31F3N2O4 | ||
Mol. Mass. | 528.5626 | ||
SMILES | COc1ccc2ncc(F)c([C@@H](O)CC[C@@H]3CCN(C[C@@H]3C(O)=O)C3CC(C3)c3cccc(F)c3F)c2c1 |r,wU:11.11,15.14,20.21,(2.38,-12.28,;3.72,-11.51,;5.04,-12.28,;5.04,-13.83,;6.38,-14.59,;7.71,-13.82,;9.05,-14.58,;10.38,-13.81,;10.37,-12.26,;11.7,-11.48,;9.04,-11.5,;9.03,-9.96,;7.69,-9.2,;10.36,-9.18,;11.7,-9.94,;13.03,-9.17,;14.36,-9.94,;15.68,-9.17,;15.68,-7.63,;14.35,-6.86,;13.01,-7.64,;11.68,-6.87,;10.35,-7.65,;11.67,-5.33,;17.02,-6.85,;18.5,-7.26,;18.89,-5.77,;17.4,-5.37,;20.22,-5,;21.55,-5.78,;22.89,-5,;22.88,-3.46,;21.54,-2.7,;21.53,-1.16,;20.21,-3.47,;18.87,-2.71,;7.71,-12.27,;6.37,-11.51,)| | ||
Structure |