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TargetNicotinamide phosphoribosyltransferase
LigandBDBM217157
Substrate/Competitorn/a
Meas. Tech.ChEBML_1686176
Ki 57±n/a nM
Citation Curtin, MLHeyman, HRClark, RFSorensen, BKDoherty, GAHansen, TMFrey, RRSarris, KAAguirre, ALShrestha, ATu, NWoller, KPliushchev, MASweis, RFCheng, MWilsbacher, JLKovar, PJGuo, JCheng, DLongenecker, KLRaich, DKorepanova, AVSoni, NBAlgire, MARichardson, PLMarin, VLBadagnani, IVasudevan, ABuchanan, FGMaag, DChiang, GGTse, CMichaelides, MR SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT). Bioorg Med Chem Lett27:3317-3325 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Nicotinamide phosphoribosyltransferase
Name:Nicotinamide phosphoribosyltransferase
Synonyms:NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1
Type:Enzyme
Mol. Mass.:55524.98
Organism:Homo sapiens (Human)
Description:P43490
Residue:491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFY
GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVP
EGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS
GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGY
SVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV
SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINT
LQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD
PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNA
QLNIELEAAHH
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  Blast E-value cutoff:
BDBM217157
n/a
NameBDBM217157
Synonyms:US9302989, 574
TypeSmall organic molecule
Emp. Form.C20H24N4O2
Mol. Mass.352.4302
SMILESCC(C)CCNC(=O)c1ccc(NC(=O)N2Cc3ccccc3C2)cn1
Structure
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