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TargetNicotinamide phosphoribosyltransferase
LigandBDBM50435350
Substrate/Competitorn/a
Meas. Tech.ChEBML_1686176
Ki 3.0±n/a nM
Citation Curtin, MLHeyman, HRClark, RFSorensen, BKDoherty, GAHansen, TMFrey, RRSarris, KAAguirre, ALShrestha, ATu, NWoller, KPliushchev, MASweis, RFCheng, MWilsbacher, JLKovar, PJGuo, JCheng, DLongenecker, KLRaich, DKorepanova, AVSoni, NBAlgire, MARichardson, PLMarin, VLBadagnani, IVasudevan, ABuchanan, FGMaag, DChiang, GGTse, CMichaelides, MR SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT). Bioorg Med Chem Lett27:3317-3325 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Nicotinamide phosphoribosyltransferase
Name:Nicotinamide phosphoribosyltransferase
Synonyms:NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1
Type:Enzyme
Mol. Mass.:55524.98
Organism:Homo sapiens (Human)
Description:P43490
Residue:491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFY
GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVP
EGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS
GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGY
SVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV
SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINT
LQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD
PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNA
QLNIELEAAHH
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50435350
n/a
NameBDBM50435350
Synonyms:CHEMBL17289
TypeSmall organic molecule
Emp. Form.C19H22ClN5O
Mol. Mass.371.864
SMILESClc1ccc(OCCCCCCNC(Nc2ccncc2)=NC#N)cc1 |w:21.22|
Structure
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