| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Acetylcholine receptor subunit alpha/beta/delta/gamma |
|---|
| Ligand | BDBM50000690 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_144963 (CHEMBL755081) |
|---|
| EC50 | 3200000±n/a nM |
|---|
| Citation |  Abramson, SN; Trischman, JA; Tapiolas, DM; Harold, EE; Fenical, W; Taylor, P Structure/activity and molecular modeling studies of the lophotoxin family of irreversible nicotinic receptor antagonists. J Med Chem34:1798-804 (1991) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Acetylcholine receptor subunit alpha/beta/delta/gamma |
|---|
| Name: | Acetylcholine receptor subunit alpha/beta/delta/gamma |
|---|
| Synonyms: | Acetylcholine receptor | Acetylcholine receptor protein alpha/beta/delta/gamma chain |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of EBI is 143080 |
|---|
| Components: | This complex has 4 components. |
|---|
| Component 1 |
| Name: | Acetylcholine receptor subunit beta |
|---|
| Synonyms: | ACHB_TETCF | Acetylcholine receptor | CHRNB1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 56146.98 |
|---|
| Organism: | Torpedo californica |
|---|
| Description: | EBI_19626 |
|---|
| Residue: | 493 |
|---|
| Sequence: | MENVRRMALGLVVMMALALSGVGASVMEDTLLSVLFETYNPKVRPAQTVGDKVTVRVGLT
LTNLLILNEKIEEMTTNVFLNLAWTDYRLQWDPAAYEGIKDLRIPSSDVWQPDIVLMNNN
DGSFEITLHVNVLVQHTGAVSWQPSAIYRSSCTIKVMYFPFDWQNCTMVFKSYTYDTSEV
TLQHALDAKGEREVKEIVINKDAFTENGQWSIEHKPSRKNWRSDDPSYEDVTFYLIIQRK
PLFYIVYTIIPCILISILAILVFYLPPDAGEKMSLSISALLAVTVFLLLLADKVPETSLS
VPIIIRYLMFIMILVAFSVILSVVVLNLHHRSPNTHTMPNWIRQIFIETLPPFLWIQRPV
TTPSPDSKPTIISRANDEYFIRKPAGDFVCPVDNARVAVQPERLFSEMKWHLNGLTQPVT
LPQDLKEAVEAIKYIAEQLESASEFDDLKKDWQYVAMVADRLFLYVFFVICSIGTFSIFL
DASHNVPPDNPFA
|
|
|
|---|
| Component 2 |
| Name: | Acetylcholine receptor subunit gamma |
|---|
| Synonyms: | ACHG_TETCF | Acetylcholine receptor | CHRNG |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 58151.68 |
|---|
| Organism: | Torpedo californica |
|---|
| Description: | EBI_19662 |
|---|
| Residue: | 506 |
|---|
| Sequence: | MVLTLLLIICLALEVRSENEEGRLIEKLLGDYDKRIIPAKTLDHIIDVTLKLTLTNLISL
NEKEEALTTNVWIEIQWNDYRLSWNTSEYEGIDLVRIPSELLWLPDVVLENNVDGQFEVA
YYANVLVYNDGSMYWLPPAIYRSTCPIAVTYFPFDWQNCSLVFRSQTYNAHEVNLQLSAE
EGEAVEWIHIDPEDFTENGEWTIRHRPAKKNYNWQLTKDDTDFQEIIFFLIIQRKPLFYI
INIIAPCVLISSLVVLVYFLPAQAGGQKCTLSISVLLAQTIFLFLIAQKVPETSLNVPLI
GKYLIFVMFVSMLIVMNCVIVLNVSLRTPNTHSLSEKIKHLFLGFLPKYLGMQLEPSEET
PEKPQPRRRSSFGIMIKAEEYILKKPRSELMFEEQKDRHGLKRVNKMTSDIDIGTTVDLY
KDLANFAPEIKSCVEACNFIAKSTKEQNDSGSENENWVLIGKVIDKACFWIALLLFSIGT
LAIFLTGHFNQVPEFPFPGDPRKYVP
|
|
|
|---|
| Component 3 |
| Name: | Acetylcholine receptor subunit alpha |
|---|
| Synonyms: | ACHA_TETCF | Acetylcholine receptor | Acetylcholine receptor protein alpha chain | CHRNA1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 52735.09 |
|---|
| Organism: | Torpedo californica |
|---|
| Description: | ChEMBL_216981 |
|---|
| Residue: | 461 |
|---|
| Sequence: | MILCSYWHVGLVLLLFSCCGLVLGSEHETRLVANLLENYNKVIRPVEHHTHFVDITVGLQ
LIQLISVDEVNQIVETNVRLRQQWIDVRLRWNPADYGGIKKIRLPSDDVWLPDLVLYNNA
DGDFAIVHMTKLLLDYTGKIMWTPPAIFKSYCEIIVTHFPFDQQNCTMKLGIWTYDGTKV
SISPESDRPDLSTFMESGEWVMKDYRGWKHWVYYTCCPDTPYLDITYHFIMQRIPLYFVV
NVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGK
YMLFTMIFVISSIIITVVVINTHHRSPSTHTMPQWVRKIFIDTIPNVMFFSTMKRASKEK
QENKIFADDIDISDISGKQVTGEVIFQTPLIKNPDVKSAIEGVKYIAEHMKSDEESSNAA
EEWKYVAMVIDHILLCVFMLICIIGTVSVFAGRLIELSQEG
|
|
|
|---|
| Component 4 |
| Name: | Acetylcholine receptor subunit delta |
|---|
| Synonyms: | ACHD_TETCF | Acetylcholine receptor | Acetylcholine receptor protein delta chain | chrnd |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 59885.01 |
|---|
| Organism: | Torpedo californica |
|---|
| Description: | ChEMBL_142744 |
|---|
| Residue: | 522 |
|---|
| Sequence: | MGNIHFVYLLISCLYYSGCSGVNEEERLINDLLIVNKYNKHVRPVKHNNEVVNIALSLTL
SNLISLKETDETLTSNVWMDHAWYDHRLTWNASEYSDISILRLPPELVWIPDIVLQNNND
GQYHVAYFCNVLVRPNGYVTWLPPAIFRSSCPINVLYFPFDWQNCSLKFTALNYDANEIT
MDLMTDTIDGKDYPIEWIIIDPEAFTENGEWEIIHKPAKKNIYPDKFPNGTNYQDVTFYL
IIRRKPLFYVINFITPCVLISFLASLAFYLPAESGEKMSTAISVLLAQAVFLLLTSQRLP
ETALAVPLIGKYLMFIMSLVTGVIVNCGIVLNFHFRTPSTHVLSTRVKQIFLEKLPRILH
MSRADESEQPDWQNDLKLRRSSSVGYISKAQEYFNIKSRSELMFEKQSERHGLVPRVTPR
IGFGNNNENIAASDQLHDEIKSGIDSTNYIVKQIKEKNAYDEEVGNWNLVGQTIDRLSMF
IITPVMVLGTIFIFVMGNFNHPPAKPFEGDPFDYSSDHPRCA
|
|
|
|---|
| BDBM50000690 |
|---|
| n/a |
|---|
| Name | BDBM50000690 |
|---|
| Synonyms: | 10,25-dimethoxy-15,15,30-trimethyl-(1S,16R)-7,23-dioxa-15,30-diazoniaheptacyclo[22.6.2.23,6.112,16.118,22.08,36.027,31]hexatriaconta-3,5,8,10,12(36),18,20,22(35),24(32),25,27(31),33-dodecaene-9,21-diol,dichloride(tubocurarine) | CHEMBL501646 | Tubocurarine | Tubocurarine dichloride | Tubocurarine,d |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C37H42N2O6 |
|---|
| Mol. Mass. | 610.7381 |
|---|
| SMILES | COc1cc2CC[N+](C)(C)[C@@H]3Cc4ccc(O)c(Oc5cc6[C@H](Cc7ccc(Oc(c1O)c23)cc7)[NH+](C)CCc6cc5OC)c4 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
