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TargetTransient receptor potential cation channel subfamily A member 1
LigandBDBM50254439
Substrate/Competitorn/a
Meas. Tech.ChEBML_1686336
IC50 8.0±n/a nM
Citation Pryde, DCMarron, BEWest, CWReister, SAmato, GYoger, KAntonio, BPadilla, KCox, PJTurner, JWarmus, JSSwain, NAOmoto, KMahoney, JHGerlach, AC Discovery of a Series of Indazole TRPA1 Antagonists. ACS Med Chem Lett8:666-671 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Transient receptor potential cation channel subfamily A member 1
Name:Transient receptor potential cation channel subfamily A member 1
Synonyms:Anktm1 | TRPA1_RAT | Trpa1
Type:PROTEIN
Mol. Mass.:128622.74
Organism:Rattus norvegicus
Description:ChEMBL_1450487
Residue:1125
Sequence:
MKRSLRRVLRPEERKEVQGVVYRGVGKDMDCSKESFKVDIEGDMCRLEAFIKNRRKLSKY
EDENLCLLHHAAAEGQVELMQLIINGSSCEALNVMDDYGNTPLHWAAEKNQVESVKFLLS
QGANPNLRNRNMMAPLHIAVQGMYNEVIKVLTEHKATNINLEGENGNTALMSTCAKDNSE
ALQILLEKGAKLCKSNKWGDYPVHQAAFSGAKRCMELILAYGEKTGYSREAHINFVNHKK
ASPLHLAVQSGDLDMIKMCLDSGAHIDMMENAKCMALHFAATQGATDIVKLMISSYTGSS
DIVNAVDGNQETLLHRASLFDHHDLADYLISVGADINSTDSEGRSPLILATASASWNIVN
LLLSKGAKVDIKDHLGRNFLHLTVQQPYGLRNLRPEFLQMQHIKELVMDEDNDGCTPLHY
ACRQGAPVSVNNLLRFNVSVHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGD
LHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLK
CTDRLDEEGNTALHFAAREGHAKAVAMLLSYNADILLNKKQASFLHIALHNKRKEVVLTT
IRSKRWDECLQVFTHDSPSNRCPIMEMVEYLPECMKVLLDFCMIPSTEDKSCQDYHIEYN
FKYLQCPLSMTKKVTPTQDVIYEPLTILNVMVQHNRIELLNHPVCREYLLMKWCAYGFRA
HMMNLGSYCLGLIPMTLLVVKIQPGMAFNSTGIINETISTHEERINTLNSFPLKICMILV
FLSSIFGYCKEVVQIFQQKRNYFLDYNNALEWVIYTTSMIFVLPLFLDIPAYMQWQCGAI
AIFFYWMNFLLYLQRFENCGIFIVMLEVIFKTLLRSTGVFIFLLLAFGLSFYVLLNFQDA
FSTPLLSLIQTFSMMLGDINYRDAFLEPLFRNELAYPVLTFGQLIAFTMFVPIVLMNLLI
GLAVGDIAEVQKHASLKRIAMQVELHTNLEKKLPFWYLRKVDQRSTIVYPNRPRHGRMLR
FFHYFLSMQETRQEAPNIDTCLEMEILKQKYRLKDLTSLLEKQHELIKLIIQKMEIISET
EDEDNHCSFQDRFKKERLEQMHSKWNFVLNAVKTKTHCSISHPDI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50254439
n/a
NameBDBM50254439
Synonyms:CHEMBL4091459
TypeSmall organic molecule
Emp. Form.C15H8F4N4O
Mol. Mass.336.2438
SMILESFc1ccc2[nH]c(cc2c1)-c1n[nH]c2cc(OC(F)(F)F)cnc12
Structure
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