| Reaction Details |
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 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 6 |
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| Ligand | BDBM50007548 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1687017 (CHEMBL4037496) |
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| EC50 | 2400±n/a nM |
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| Citation |  Selvam, C; Lemasson, IA; Brabet, I; Oueslati, N; Karaman, B; Cabaye, A; Tora, AS; Commare, B; Courtiol, T; Cesarini, S; McCort-Tranchepain, I; Rigault, D; Mony, L; Bessiron, T; McLean, H; Leroux, FR; Colobert, F; Daniel, H; Goupil-Lamy, A; Bertrand, HO; Goudet, C; Pin, JP; Acher, FC Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites. J Med Chem61:1969-1989 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Metabotropic glutamate receptor 6 |
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| Name: | Metabotropic glutamate receptor 6 |
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| Synonyms: | GPRC1F | GRM6 | GRM6_HUMAN | MGLUR6 | Metabotropic glutamate receptor 6 | glutamate receptor, metabotropic 6 precursor | metabotropic glutamate 6 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 95479.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | metabotropic glutamate 6 GRM6 HUMAN::O15303 |
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| Residue: | 877 |
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| Sequence: | MARPRRAREPLLVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHARGAAGRACGQL
KKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGR
GDGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPE
LSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREA
GGVCIAQSIKIPREPKPGEFSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANLTGH
FLWVGSDSWGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEF
WEENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQ
ALCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNG
SASSGGYQAVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHC
EACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVAT
TTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLG
TTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARP
PHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFN
EAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKT
YVILFHPEQNVQKRKRSLKATSTVAAPPKGEDAEAHK
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| BDBM50007548 |
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| n/a |
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| Name | BDBM50007548 |
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| Synonyms: | (S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino-4-phosphonobutanoic acid | 2-Amino-3-(3,5-dioxo-[1,2,4]oxadiazolidin-2-yl)-propionic acid | 2-Amino-4-phosphono-butyric acid | 2-Amino-4-phosphono-butyric acid(S-AP4) | 2-amino-4-phosphonobutanoic acid | 2-amino-4-phosphonobutyric acid | CHEMBL33567 | L-(+)-2-amino-4-phosphonobutyric acid | L-1-amino-4-phosphonobutanoic acid | L-AP4 | L-APB |
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| Type | Small organic molecule |
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| Emp. Form. | C4H10NO5P |
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| Mol. Mass. | 183.0997 |
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| SMILES | N[C@@H](CCP(O)(O)=O)C(O)=O |r| |
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| Structure | 
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