Reaction Details |
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Target | Fatty-acid amide hydrolase 1 |
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Ligand | BDBM50255776 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_1687489 |
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IC50 | 4300±n/a nM |
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Citation | McAllister, LA; Butler, CR; Mente, S; O'Neil, SV; Fonseca, KR; Piro, JR; Cianfrogna, JA; Foley, TL; Gilbert, AM; Harris, AR; Helal, CJ; Johnson, DS; Montgomery, JI; Nason, DM; Noell, S; Pandit, J; Rogers, BN; Samad, TA; Shaffer, CL; da Silva, RG; Uccello, DP; Webb, D; Brodney, MA Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation. J Med Chem61:3008-3026 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Fatty-acid amide hydrolase 1 |
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Name: | Fatty-acid amide hydrolase 1 |
Synonyms: | Anandamide amidohydrolase | Anandamide amidohydrolase 1 | FAAH | FAAH1 | FAAH1_HUMAN | Fatty Acid Amide Hydrolase (FAAH) | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Oleamide hydrolase 1 |
Type: | Protein |
Mol. Mass.: | 63071.19 |
Organism: | Homo sapiens (Human) |
Description: | O00519 |
Residue: | 579 |
Sequence: | MVQYELWAALPGASGVALACCFVAAAVALRWSGRRTARGAVVRARQRQRAGLENMDRAAQ
RFRLQNPDLDSEALLALPLPQLVQKLHSRELAPEAVLFTYVGKAWEVNKGTNCVTSYLAD
CETQLSQAPRQGLLYGVPVSLKECFTYKGQDSTLGLSLNEGVPAECDSVVVHVLKLQGAV
PFVHTNVPQSMFSYDCSNPLFGQTVNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGG
SIRFPSSFCGICGLKPTGNRLSKSGLKGCVYGQEAVRLSVGPMARDVESLALCLRALLCE
DMFRLDPTVPPLPFREEVYTSSQPLRVGYYETDNYTMPSPAMRRAVLETKQSLEAAGHTL
VPFLPSNIPHALETLSTGGLFSDGGHTFLQNFKGDFVDPCLGDLVSILKLPQWLKGLLAF
LVKPLLPRLSAFLSNMKSRSAGKLWELQHEIEVYRKTVIAQWRALDLDVVLTPMLAPALD
LNAPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDEAQMEHYRGYFGDIWDKMLQKGMK
KSVGLPVAVQCVALPWQEELCLRFMREVERLMTPEKQSS
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BDBM50255776 |
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n/a |
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Name | BDBM50255776 |
Synonyms: | CHEMBL4075310 |
Type | Small organic molecule |
Emp. Form. | C18H14F7N3O2 |
Mol. Mass. | 437.3115 |
SMILES | [H][C@@]12CN(C[C@]1([H])[C@H]2c1ccn(n1)-c1ccc(F)cc1)C(=O)OC(C(F)(F)F)C(F)(F)F |r| |
Structure |
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