Reaction Details |
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Target | Cholinesterase |
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Ligand | BDBM50256407 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_1687867 |
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IC50 | 24970±n/a nM |
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Citation | Dias, KS; de Paula, CT; Dos Santos, T; Souza, IN; Boni, MS; Guimarães, MJ; da Silva, FM; Castro, NG; Neves, GA; Veloso, CC; Coelho, MM; de Melo, IS; Giusti, FC; Giusti-Paiva, A; da Silva, ML; Dardenne, LE; Guedes, IA; Pruccoli, L; Morroni, F; Tarozzi, A; Viegas, C Design, synthesis and evaluation of novel feruloyl-donepezil hybrids as potential multitarget drugs for the treatment of Alzheimer's disease. Eur J Med Chem130:440-457 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cholinesterase |
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Name: | Cholinesterase |
Synonyms: | BCHE | Butyrylcholinesterase (BuChE) | CHLE_HORSE | Cholinesterase |
Type: | Enzyme |
Mol. Mass.: | 65643.35 |
Organism: | Equus caballus (Horse) |
Description: | P81908 |
Residue: | 574 |
Sequence: | EEDIIITTKNGKVRGMNLPVLGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSNIWNATK
YANSCYQNTDQSFPGFLGSEMWNPNTELSEDCLYLNVWIPAPKPKNATVMIWIYGGGFQT
GTSSLPVYDGKFLARVERVIVVSMNYRVGALGFLALSENPEAPGNMGLFDQQLALQWVQK
NIAAFGGNPRSVTLFGESAGAASVSLHLLSPRSQPLFTRAILQSGSSNAPWAVTSLYEAR
NRTLTLAKRMGCSRDNETEMIKCLRDKDPQEILLNEVFVVPYDTLLSVNFGPTVDGDFLT
DMPDTLLQLGQFKRTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPR
VSEFGRESILFHYMDWLDDQRAENYREALDDVVGDYNIICPALEFTRKFSELGNDAFFYY
FEHRSTKLPWPEWMGVMHGYEIEFVFGLPLERRVNYTRAEEILSRSIMKRWANFAKYGNP
NGTQNNSTRWPVFKSTEQKYLTLNTESPKVYTKLRAQQCRFWTLFFPKVLELTGNIDEAE
REWKAGFHRWNNYMMDWKNQFNDYTSKKESCSDF
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BDBM50256407 |
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n/a |
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Name | BDBM50256407 |
Synonyms: | CHEMBL4088197 |
Type | Small organic molecule |
Emp. Form. | C23H27NO4 |
Mol. Mass. | 381.4648 |
SMILES | COc1cc(\C=C\C(=O)OCC2CCN(Cc3ccccc3)CC2)ccc1O |
Structure |
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