Ki Summary

Reaction Details

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Target

C5a anaphylatoxin chemotactic receptor 1

Ligand

BDBM50008233

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_41471

5300±n/a nM

Citation

Kawai, M; Quincy, DA; Lane, B; Mollison, KW; Or, YS; Luly, JR; Carter, GW Structure-function studies in a series of carboxyl-terminal octapeptide analogues of anaphylatoxin C5a. J Med Chem35:220-3 (1992) [PubMed]

More Info.:

Get all data from this article, Assay Method

C5a anaphylatoxin chemotactic receptor 1

Name:

C5a anaphylatoxin chemotactic receptor 1

Synonyms:

C5AR | C5AR1 | C5AR1_HUMAN | C5R1 | C5a anaphylatoxin chemotactic receptor | C5a anaphylatoxin chemotactic receptor (C5aR) | C5a-R | CD_antigen=CD88

Type:

Enzyme

Mol. Mass.:

39347.68

Organism:

Homo sapiens (Human)

Description:

P21730

Residue:

350

Sequence:

MDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVW
VTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNM
YASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREE
YFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKT
LKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIY
VVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV

BDBM50008233

n/a

Name

BDBM50008233

Synonyms:

2-[2-(2-{2-[2-(2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-6-amino-hexanoylamino}-3-carboxy-propionylamino)-3-cyclohexyl-propionylamino]-3-cyclohexyl-propionylamino}-3-cyclohexyl-propionylamino)-propionylamino]-5-guanidino-pentanoic acid | CHEMBL3350714

Type

Small organic molecule

Emp. Form.

C50H84N14O12

Mol. Mass.

1073.2886

SMILES

CCC[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]cn1)NC(C)=O)C(=O)N[C@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O |r,wU:29.31,46.48,7.7,wD:18.19,3.2,37.39,65.68,60.63,(23.35,-14.99,;23.32,-13.44,;24.63,-12.64,;24.59,-11.11,;23.24,-10.37,;21.93,-11.16,;21.97,-12.7,;20.58,-10.42,;20.55,-8.89,;21.87,-8.08,;23.22,-8.82,;24.53,-8.03,;24.5,-6.48,;23.15,-5.74,;21.84,-6.55,;19.27,-11.22,;17.91,-10.48,;17.88,-8.94,;16.6,-11.27,;16.64,-12.81,;17.98,-13.55,;19.3,-12.75,;20.65,-13.49,;20.68,-15.04,;19.36,-15.84,;18.02,-15.1,;15.25,-10.53,;13.94,-11.33,;13.97,-12.86,;12.59,-10.59,;12.55,-9.05,;13.86,-8.26,;15.21,-9,;13.84,-6.72,;11.27,-11.38,;9.92,-10.64,;9.89,-9.11,;8.61,-11.44,;8.64,-12.99,;9.99,-13.73,;10.02,-15.27,;11.37,-16.01,;11.4,-17.54,;7.26,-10.7,;5.94,-11.5,;5.98,-13.04,;4.59,-10.75,;4.56,-9.22,;5.87,-8.42,;7.3,-9.02,;8.29,-7.85,;7.5,-6.54,;6,-6.89,;3.27,-11.56,;1.92,-10.81,;.61,-11.62,;1.89,-9.28,;25.91,-10.31,;25.88,-8.77,;27.26,-11.05,;28.58,-10.26,;28.55,-8.71,;29.92,-11,;29.96,-12.53,;31.25,-10.19,;32.6,-10.94,;32.62,-12.48,;33.97,-13.22,;34.01,-14.75,;35.36,-15.49,;35.39,-17.04,;36.74,-17.78,;34.08,-17.83,;33.91,-10.14,;35.26,-10.88,;33.88,-8.6,)|

Structure