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TargetAldo-keto reductase family 1 member B1
LigandBDBM50008471
Substrate/Competitorn/a
Meas. Tech.ChEBML_31764
IC50 3.2±n/a nM
Citation Mylari, BLBeyer, TAScott, PJAldinger, CEDee, MFSiegel, TWZembrowski, WJ Potent, orally active aldose reductase inhibitors related to zopolrestat: surrogates for benzothiazole side chain. J Med Chem35:457-65 (1992) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Aldo-keto reductase family 1 member B1
Name:Aldo-keto reductase family 1 member B1
Synonyms:AKR1B1 | ALDR1 | ALDR_HUMAN | ALR2 | AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase | Aldose reductase (AR)
Type:Protein
Mol. Mass.:35855.50
Organism:Homo sapiens (Human)
Description:P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0
Residue:316
Sequence:
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ
EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK
EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP
AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA
LLSCTSHKDYPFHEEF
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  Blast E-value cutoff:
BDBM50008471
n/a
NameBDBM50008471
Synonyms:CHEMBL143234 | [3-(5,7-Difluoro-benzooxazol-2-ylmethyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-acetic acid
TypeSmall organic molecule
Emp. Form.C18H11F2N3O4
Mol. Mass.371.2944
SMILESOC(=O)Cc1nn(Cc2nc3cc(F)cc(F)c3o2)c(=O)c2ccccc12
Structure
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