| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 1A |
|---|
| Ligand | BDBM50004769 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_1691076 |
|---|
| Ki | 0.588844±n/a nM |
|---|
| Citation |  Del Bello, F; Bonifazi, A; Giannella, M; Giorgioni, G; Piergentili, A; Petrelli, R; Cifani, C; Micioni Di Bonaventura, MV; Keck, TM; Mazzolari, A; Vistoli, G; Cilia, A; Poggesi, E; Matucci, R; Quaglia, W The replacement of the 2-methoxy substituent of N-((6,6-diphenyl-1,4-dioxan-2-yl)methyl)-2-(2-methoxyphenoxy)ethan-1-amine improves the selectivity for 5-HT Eur J Med Chem125:233-244 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 5-hydroxytryptamine receptor 1A |
|---|
| Name: | 5-hydroxytryptamine receptor 1A |
|---|
| Synonyms: | 5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 46122.49 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 422 |
|---|
| Sequence: | MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADT
RHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGN
SKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RQ
|
|
|
|---|
| BDBM50004769 |
|---|
| n/a |
|---|
| Name | BDBM50004769 |
|---|
| Synonyms: | CHEMBL2312537 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H27NO3 |
|---|
| Mol. Mass. | 389.4868 |
|---|
| SMILES | C(COc1ccccc1)NCC1COCC(O1)(c1ccccc1)c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
