| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H4 receptor |
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| Ligand | BDBM50325747 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1691274 (CHEMBL4041923) |
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| Ki | 5.2±n/a nM |
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| Citation |  Levoin, N; Labeeuw, O; Billot, X; Calmels, T; Danvy, D; Krief, S; Berrebi-Bertrand, I; Lecomte, JM; Schwartz, JC; Capet, M Discovery of nanomolar ligands with novel scaffolds for the histamine H4 receptor by virtual screening. Eur J Med Chem125:565-572 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H4 receptor |
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| Name: | Histamine H4 receptor |
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| Synonyms: | AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44517.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Binding assays were using CHO cells stably expressing hH4R receptors. |
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| Residue: | 390 |
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| Sequence: | MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV
SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF
LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA
STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR
LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL
CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
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| BDBM50325747 |
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| n/a |
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| Name | BDBM50325747 |
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| Synonyms: | CHEMBL1223749 | N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)isoquinolin-1-amine |
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| Type | Small organic molecule |
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| Emp. Form. | C23H26Cl2N4 |
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| Mol. Mass. | 429.385 |
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| SMILES | Clc1cccc(N2CCN(CCCCNc3nccc4ccccc34)CC2)c1Cl |
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| Structure | 
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