| Reaction Details |
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 | Report a problem with these data |
| Target | Cysteinyl leukotriene receptor 1 |
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| Ligand | BDBM50291858 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_52358 |
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| Ki | 2.5±n/a nM |
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| Citation |  Huang, FC; Galemmo, RA; Poli, GB; Learn, KS; Morrissette, MM; Johnson, WH; Dankulich, WP; Campbell, HF; Carnathan, GW; VanInwegen, RG Development of a novel series of (2-quinolinylmethoxy)phenyl-containing compounds as high-affinity leukotriene D4 receptor antagonists. 4. Addition of chromone moiety enhances leukotriene D4 receptor binding affinity. J Med Chem34:1704-7 (1991) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Cysteinyl leukotriene receptor 1 |
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| Name: | Cysteinyl leukotriene receptor 1 |
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| Synonyms: | CLTR1_CAVPO | CYSLTR1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 39007.58 |
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| Organism: | GUINEA PIG |
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| Description: | Leukotriene D4 0 GUINEA PIG::Q2NNR5 |
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| Residue: | 340 |
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| Sequence: | MDETGNPTIPPASNNTCYDSIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLVKTYHEKSA
FQVYMINLAVADLLCVCTLPLRVAYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAM
SFFRCVAIVFPVQNISLVTQKKARLVCIAIWMFVILTSSPFLMANTYKDEKNNTKCFEPP
QDNQAKNYVLILHYVSLFIGFIIPFITIIVCYTMIIFTLLKSSMKKNLSSRKRAIGMIIV
VTAAFLVSFMPYHIQRTIHLHFLHNKTKPCDSILRMQKSVVITLSLAASNCCFDPLLYFF
SGGNFRRRLSTIRKYSLSSMTYIPKKKTSLPQKGKDICKE
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| BDBM50291858 |
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| n/a |
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| Name | BDBM50291858 |
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| Synonyms: | 7-{2-[3-(Quinolin-2-ylmethoxy)-phenyl]-vinyl}-2-(1H-tetrazol-5-yl)-chroman-4-one | CHEMBL47376 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H21N5O3 |
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| Mol. Mass. | 475.498 |
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| SMILES | O=C1CC(Oc2cc(\C=C\c3cccc(OCc4ccc5ccccc5n4)c3)ccc12)c1nnn[nH]1 |
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| Structure | 
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