| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cysteinyl leukotriene receptor 1 |
|---|
| Ligand | BDBM50291853 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_52358 |
|---|
| Ki | 6.3±n/a nM |
|---|
| Citation |  Huang, FC; Galemmo, RA; Poli, GB; Learn, KS; Morrissette, MM; Johnson, WH; Dankulich, WP; Campbell, HF; Carnathan, GW; VanInwegen, RG Development of a novel series of (2-quinolinylmethoxy)phenyl-containing compounds as high-affinity leukotriene D4 receptor antagonists. 4. Addition of chromone moiety enhances leukotriene D4 receptor binding affinity. J Med Chem34:1704-7 (1991) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cysteinyl leukotriene receptor 1 |
|---|
| Name: | Cysteinyl leukotriene receptor 1 |
|---|
| Synonyms: | CLTR1_CAVPO | CYSLTR1 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 39007.58 |
|---|
| Organism: | GUINEA PIG |
|---|
| Description: | Leukotriene D4 0 GUINEA PIG::Q2NNR5 |
|---|
| Residue: | 340 |
|---|
| Sequence: | MDETGNPTIPPASNNTCYDSIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLVKTYHEKSA
FQVYMINLAVADLLCVCTLPLRVAYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAM
SFFRCVAIVFPVQNISLVTQKKARLVCIAIWMFVILTSSPFLMANTYKDEKNNTKCFEPP
QDNQAKNYVLILHYVSLFIGFIIPFITIIVCYTMIIFTLLKSSMKKNLSSRKRAIGMIIV
VTAAFLVSFMPYHIQRTIHLHFLHNKTKPCDSILRMQKSVVITLSLAASNCCFDPLLYFF
SGGNFRRRLSTIRKYSLSSMTYIPKKKTSLPQKGKDICKE
|
|
|
|---|
| BDBM50291853 |
|---|
| n/a |
|---|
| Name | BDBM50291853 |
|---|
| Synonyms: | 4-Oxo-7-[4-(quinolin-2-ylmethoxy)-phenoxymethyl]-chroman-2-carboxylic acid | CHEMBL295368 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H21NO6 |
|---|
| Mol. Mass. | 455.4587 |
|---|
| SMILES | OC(=O)C1CC(=O)c2ccc(COc3ccc(OCc4ccc5ccccc5n4)cc3)cc2O1 |
|---|
| Structure | 
|
|---|
Search and Browse
