Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | 5-hydroxytryptamine receptor 3A | ||
Ligand | BDBM50259915 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEBML_1691999 | ||
IC50 | 38±n/a nM | ||
Citation | Hill, MD; Fang, H; Digavalli, SV; Healy, FL; Gallagher, L; Post-Munson, D; Chen, P; Natale, J; Benitex, Y; Morgan, D; Lodge, N; Bristow, L; Macor, JE; Olson, RE Development of spiroguanidine-derived?7 neuronal nicotinic receptor partial agonists. Bioorg Med Chem Lett27:578-581 (2017) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
5-hydroxytryptamine receptor 3A | |||
Name: | 5-hydroxytryptamine receptor 3A | ||
Synonyms: | 5-HT-3 | 5-HT3 | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 (5-HT3) | 5-hydroxytryptamine receptor 3A (5-HT3a) | 5-hydroxytryptamine receptor 3A (5HT3A) | 5HT3A_HUMAN | 5HT3R | HTR3 | HTR3A | Serotonin 3 (5-HT3) receptor | Serotonin 3 receptor (5HT3) | Serotonin receptor 3A | Serotonin-gated ion channel receptor | Serotonin-gated ion channel receptor 3 | ||
Type: | Protein | ||
Mol. Mass.: | 55283.27 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P46098 | ||
Residue: | 478 | ||
Sequence: |
| ||
BDBM50259915 | |||
n/a | |||
Name | BDBM50259915 | ||
Synonyms: | CHEMBL4063687 | ||
Type | Small organic molecule | ||
Emp. Form. | C16H18ClN5S | ||
Mol. Mass. | 347.866 | ||
SMILES | Clc1cccc2sc(NC3=NCC4(CN5CCC4CC5)N3)nc12 |t:9,THB:20:12:15.16:18.19,(25.79,-33.21,;25.79,-31.67,;27.13,-30.9,;27.12,-29.35,;25.79,-28.58,;24.46,-29.35,;23,-28.88,;22.09,-30.14,;20.55,-30.14,;19.78,-31.47,;20.4,-32.87,;19.26,-33.9,;17.93,-33.13,;17.72,-34.51,;15.8,-33.71,;14.4,-34.63,;14.75,-33.24,;16.45,-32.49,;16.38,-30.85,;15.8,-32.24,;18.25,-31.63,;22.99,-31.37,;24.46,-30.9,)| | ||
Structure |