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TargetSerotonin 3 (5-HT3) receptor
LigandBDBM50259919
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1691999
IC50 26±n/a nM
Citation Hill MDFang HDigavalli SVHealy FLGallagher LPost-Munson DChen PNatale JBenitex YMorgan DLodge NBristow LMacor JEOlson RE Development of spiroguanidine-derived?7 neuronal nicotinic receptor partial agonists. Bioorg Med Chem Lett 27:578-581 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Serotonin 3 (5-HT3) receptor
Name:Serotonin 3 (5-HT3) receptor
Synonyms:5-HT-3 | 5-HT3 | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 (5-HT3) | 5-hydroxytryptamine receptor 3A (5-HT3a) | 5-hydroxytryptamine receptor 3A (5HT3A) | HTR3A | Serotonin 3 (5-HT3) receptor | Serotonin 3 receptor (5HT3) | Serotonin receptor 3A | Serotonin-gated ion channel receptor | Serotonin-gated ion channel receptor 3
Type:Protein
Mol. Mass.:55283.27
Organism:Homo sapiens (Human)
Description:P46098
Residue:478
Sequence:
MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTT
VSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDI
LINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLH
TIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRR
RPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAI
GTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQ
STSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQ
ELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
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  Blast E-value cutoff:
BDBM50259919
n/a
NameBDBM50259919
Synonyms:CHEMBL4080813
TypeSmall organic molecule
Emp. Form.C16H19N5S
Mol. Mass.313.421
SMILESC1N=C(Nc2nc3ccccc3s2)NC11CN2CCC1CC2 |t:1,THB:13:14:17.18:20.21,(18.15,-25.42,;19.3,-24.39,;18.67,-22.98,;19.44,-21.65,;20.99,-21.65,;21.89,-22.89,;23.36,-22.41,;24.69,-23.18,;26.03,-22.41,;26.02,-20.86,;24.69,-20.1,;23.36,-20.87,;21.9,-20.39,;17.14,-23.14,;16.82,-24.65,;16.61,-26.03,;14.69,-25.23,;13.29,-26.15,;13.64,-24.76,;15.33,-24,;15.27,-22.36,;14.68,-23.75,)|
Structure
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