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TargetNeuronal acetylcholine receptor subunit alpha-7
LigandBDBM50259926
Substrate/Competitorn/a
Meas. Tech.ChEBML_1691998
EC50 1300±n/a nM
Citation Hill, MDFang, HDigavalli, SVHealy, FLGallagher, LPost-Munson, DChen, PNatale, JBenitex, YMorgan, DLodge, NBristow, LMacor, JEOlson, RE Development of spiroguanidine-derived?7 neuronal nicotinic receptor partial agonists. Bioorg Med Chem Lett27:578-581 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Neuronal acetylcholine receptor subunit alpha-7
Name:Neuronal acetylcholine receptor subunit alpha-7
Synonyms:ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:n/a
Mol. Mass.:56448.33
Organism:Homo sapiens (Human)
Description: CHRNA7 (NACHRA7)
Residue:502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLL
QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADE
RFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDL
QMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIP
CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST
MIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHK
QRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHL
LHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTI
ICTIGILMSAPNFVEAVSKDFA
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  Blast E-value cutoff:
BDBM50259926
n/a
NameBDBM50259926
Synonyms:CHEMBL4066441
TypeSmall organic molecule
Emp. Form.C14H20N6O
Mol. Mass.288.3482
SMILESCOc1cc(NC2=NCC3(CN4CCC3CC4)N2)ncn1 |t:6,THB:17:9:12.13:15.16,(51.78,-5.03,;50.24,-5.03,;49.47,-3.69,;47.93,-3.69,;47.17,-2.35,;45.62,-2.35,;44.85,-3.69,;45.48,-5.09,;44.33,-6.12,;43,-5.35,;42.79,-6.74,;40.87,-5.93,;39.47,-6.86,;39.81,-5.46,;41.51,-4.71,;41.45,-3.07,;40.86,-4.46,;43.32,-3.84,;47.93,-1.02,;49.47,-1.01,;50.25,-2.35,)|
Structure
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