Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | 5-hydroxytryptamine receptor 3A | ||
Ligand | BDBM50259947 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEBML_1691999 | ||
IC50 | 51±n/a nM | ||
Citation | Hill, MD; Fang, H; Digavalli, SV; Healy, FL; Gallagher, L; Post-Munson, D; Chen, P; Natale, J; Benitex, Y; Morgan, D; Lodge, N; Bristow, L; Macor, JE; Olson, RE Development of spiroguanidine-derived?7 neuronal nicotinic receptor partial agonists. Bioorg Med Chem Lett27:578-581 (2017) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
5-hydroxytryptamine receptor 3A | |||
Name: | 5-hydroxytryptamine receptor 3A | ||
Synonyms: | 5-HT-3 | 5-HT3 | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 (5-HT3) | 5-hydroxytryptamine receptor 3A (5-HT3a) | 5-hydroxytryptamine receptor 3A (5HT3A) | 5HT3A_HUMAN | 5HT3R | HTR3 | HTR3A | Serotonin 3 (5-HT3) receptor | Serotonin 3 receptor (5HT3) | Serotonin receptor 3A | Serotonin-gated ion channel receptor | Serotonin-gated ion channel receptor 3 | ||
Type: | Protein | ||
Mol. Mass.: | 55283.27 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P46098 | ||
Residue: | 478 | ||
Sequence: |
| ||
BDBM50259947 | |||
n/a | |||
Name | BDBM50259947 | ||
Synonyms: | CHEMBL4085299 | ||
Type | Small organic molecule | ||
Emp. Form. | C17H21N5OS | ||
Mol. Mass. | 343.447 | ||
SMILES | COc1ccc2sc(NC3=NCC4(CN5CCC4CC5)N3)nc2c1 |t:9,THB:20:12:15.16:18.19,(15.81,-30.95,;14.47,-31.72,;13.14,-30.95,;13.14,-29.4,;11.8,-28.64,;10.47,-29.41,;9.01,-28.94,;8.1,-30.19,;6.56,-30.19,;5.79,-31.52,;6.42,-32.93,;5.27,-33.96,;3.94,-33.19,;3.73,-34.57,;1.82,-33.76,;.42,-34.69,;.77,-33.3,;2.46,-32.54,;2.4,-30.91,;1.81,-32.3,;4.26,-31.68,;9.01,-31.43,;10.47,-30.95,;11.81,-31.73,)| | ||
Structure |