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TargetSerotonin 3 (5-HT3) receptor
LigandBDBM50259947
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1691999
IC50 51±n/a nM
Citation Hill MDFang HDigavalli SVHealy FLGallagher LPost-Munson DChen PNatale JBenitex YMorgan DLodge NBristow LMacor JEOlson RE Development of spiroguanidine-derived?7 neuronal nicotinic receptor partial agonists. Bioorg Med Chem Lett 27:578-581 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Serotonin 3 (5-HT3) receptor
Name:Serotonin 3 (5-HT3) receptor
Synonyms:5-HT-3 | 5-HT3 | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 (5-HT3) | 5-hydroxytryptamine receptor 3A (5-HT3a) | 5-hydroxytryptamine receptor 3A (5HT3A) | HTR3A | Serotonin 3 (5-HT3) receptor | Serotonin 3 receptor (5HT3) | Serotonin receptor 3A | Serotonin-gated ion channel receptor | Serotonin-gated ion channel receptor 3
Type:Protein
Mol. Mass.:55283.27
Organism:Homo sapiens (Human)
Description:P46098
Residue:478
Sequence:
MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTT
VSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDI
LINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLH
TIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRR
RPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAI
GTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQ
STSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQ
ELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
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  Blast E-value cutoff:
BDBM50259947
n/a
NameBDBM50259947
Synonyms:CHEMBL4085299
TypeSmall organic molecule
Emp. Form.C17H21N5OS
Mol. Mass.343.447
SMILESCOc1ccc2sc(NC3=NCC4(CN5CCC4CC5)N3)nc2c1 |t:9,THB:20:12:15.16:18.19,(15.81,-30.95,;14.47,-31.72,;13.14,-30.95,;13.14,-29.4,;11.8,-28.64,;10.47,-29.41,;9.01,-28.94,;8.1,-30.19,;6.56,-30.19,;5.79,-31.52,;6.42,-32.93,;5.27,-33.96,;3.94,-33.19,;3.73,-34.57,;1.82,-33.76,;.42,-34.69,;.77,-33.3,;2.46,-32.54,;2.4,-30.91,;1.81,-32.3,;4.26,-31.68,;9.01,-31.43,;10.47,-30.95,;11.81,-31.73,)|
Structure
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