Reaction Details |
| Report a problem with these data |
Target | G protein-coupled receptor kinase 5 |
---|
Ligand | BDBM50173320 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEBML_1692746 |
---|
IC50 | >100000±n/a nM |
---|
Citation | Waldschmidt, HV; Homan, KT; Cato, MC; Cruz-Rodríguez, O; Cannavo, A; Wilson, MW; Song, J; Cheung, JY; Koch, WJ; Tesmer, JJ; Larsen, SD Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine. J Med Chem60:3052-3069 (2017) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
G protein-coupled receptor kinase 5 |
---|
Name: | G protein-coupled receptor kinase 5 |
Synonyms: | G protein-coupled receptor kinase 5 | G protein-coupled receptor kinase GRK5 | GPRK5 | GRK5 | GRK5_BOVIN |
Type: | PROTEIN |
Mol. Mass.: | 67903.06 |
Organism: | Bos taurus |
Description: | ChEMBL_116955 |
Residue: | 590 |
Sequence: | MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHINQCEDLRRTIDRDYCSLCDKQ
PVGRLLFRQFCETRPGLESYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFITQ
VGRDLVSQTEEKLLQKPCKELFSACVQSVHDYLRGEPFHEYLDSMYFDRFLQWKWLERQP
VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK
VNSRFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE
DLHHENIVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ
RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC
KMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDI
EQFSTVKGVNLDHTDDDFYSKFSTGSVPIPWQSEMIETECFKELNVFGPHGTLSPDLNRS
HPPEPPKKGLLQRLFKRQHQNNSKSSPNSKTSFNHHINSNHVSSNSTGSS
|
|
|
BDBM50173320 |
---|
n/a |
---|
Name | BDBM50173320 |
Synonyms: | GSK-180736A | GSK180736A | US10023564, Compound GSK180736A |
Type | Small organic molecule |
Emp. Form. | C19H16FN5O2 |
Mol. Mass. | 365.361 |
SMILES | CC1=C(C(NC(=O)N1)c1ccc(F)cc1)C(=O)Nc1ccc2[nH]ncc2c1 |t:1| |
Structure |
|