| Reaction Details |
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 | Report a problem with these data |
| Target | G protein-coupled receptor kinase 5 |
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| Ligand | BDBM50257350 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1692746 |
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| IC50 | 9200±n/a nM |
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| Citation |  Waldschmidt, HV; Homan, KT; Cato, MC; Cruz-Rodríguez, O; Cannavo, A; Wilson, MW; Song, J; Cheung, JY; Koch, WJ; Tesmer, JJ; Larsen, SD Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine. J Med Chem60:3052-3069 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| G protein-coupled receptor kinase 5 |
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| Name: | G protein-coupled receptor kinase 5 |
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| Synonyms: | G protein-coupled receptor kinase 5 | G protein-coupled receptor kinase GRK5 | GPRK5 | GRK5 | GRK5_BOVIN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 67903.06 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_116955 |
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| Residue: | 590 |
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| Sequence: | MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHINQCEDLRRTIDRDYCSLCDKQ
PVGRLLFRQFCETRPGLESYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFITQ
VGRDLVSQTEEKLLQKPCKELFSACVQSVHDYLRGEPFHEYLDSMYFDRFLQWKWLERQP
VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK
VNSRFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE
DLHHENIVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ
RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC
KMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDI
EQFSTVKGVNLDHTDDDFYSKFSTGSVPIPWQSEMIETECFKELNVFGPHGTLSPDLNRS
HPPEPPKKGLLQRLFKRQHQNNSKSSPNSKTSFNHHINSNHVSSNSTGSS
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| BDBM50257350 |
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| n/a |
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| Name | BDBM50257350 |
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| Synonyms: | CHEMBL1738877 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H21F3N6O |
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| Mol. Mass. | 466.4583 |
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| SMILES | Cn1c(CNc2cccc(c2)C(=O)NCc2ccccc2C(F)(F)F)nnc1-c1ccncc1 |
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| Structure | 
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