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TargetRhodopsin kinase GRK1
LigandBDBM50173320
Substrate/Competitorn/a
Meas. Tech.ChEBML_1692745
IC50>100000±n/a nM
Citation Waldschmidt, HVHoman, KTCato, MCCruz-Rodríguez, OCannavo, AWilson, MWSong, JCheung, JYKoch, WJTesmer, JJLarsen, SD Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine. J Med Chem60:3052-3069 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Rhodopsin kinase GRK1
Name:Rhodopsin kinase GRK1
Synonyms:G protein-coupled receptor kinase 1 | GRK1 | GRK1_BOVIN | RHOK | Rhodopsin kinase
Type:PROTEIN
Mol. Mass.:62931.24
Organism:Bos taurus
Description:ChEMBL_116985
Residue:561
Sequence:
MDFGSLETVVANSAFIAARGSFDASSGPASRDRKYLARLKLPPLSKCEALRESLDLGFEG
MCLEQPIGKRLFQQFLRTHEQHGPALQLWKDIEDYDTADDALRPQKAQALRAAYLEPQAQ
LFCSFLDAETVARARAGAGDGLFQPLLRAVLAHLGQAPFQEFLDSLYFLRFLQWKWLEAQ
PMGEDWFLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILA
KVHSRFIVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVS
GLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPEL
LLGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYPDKFSPAS
KDFCEALLQKDPEKRLGFRDGSCDGLRTHPLFRDISWRQLEAGMLTPPFVPDSRTVYAKN
IQDVGAFSTVKGVAFEKADTEFFQEFASGTCPIPWQEEMIETGVFGDLNVWRPDGQMPDD
MKGVSGQEAAPSSKSGMCVLS
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  Blast E-value cutoff:
BDBM50173320
n/a
NameBDBM50173320
Synonyms:GSK-180736A | GSK180736A | US10023564, Compound GSK180736A
TypeSmall organic molecule
Emp. Form.C19H16FN5O2
Mol. Mass.365.361
SMILESCC1=C(C(NC(=O)N1)c1ccc(F)cc1)C(=O)Nc1ccc2[nH]ncc2c1 |t:1|
Structure
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