Reaction Details |
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Target | Aldo-keto reductase family 1 member B1 |
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Ligand | BDBM50009806 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_157078 |
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IC50 | 1±n/a nM |
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Citation | Mylari, BL; Larson, ER; Beyer, TA; Zembrowski, WJ; Aldinger, CE; Dee, MF; Siegel, TW; Singleton, DH Novel, potent aldose reductase inhibitors: 3,4-dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl] methyl]-1-phthalazineacetic acid (zopolrestat) and congeners. J Med Chem34:108-22 (1991) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Aldo-keto reductase family 1 member B1 |
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Name: | Aldo-keto reductase family 1 member B1 |
Synonyms: | AKR1B1 | ALDR1 | ALDR_HUMAN | ALR2 | AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase | Aldose reductase (AR) |
Type: | Protein |
Mol. Mass.: | 35855.50 |
Organism: | Homo sapiens (Human) |
Description: | P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0 |
Residue: | 316 |
Sequence: | MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ
EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK
EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP
AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA
LLSCTSHKDYPFHEEF
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BDBM50009806 |
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n/a |
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Name | BDBM50009806 |
Synonyms: | CHEMBL20207 | [3-(7-Chloro-benzothiazol-2-ylmethyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-acetic acid |
Type | Small organic molecule |
Emp. Form. | C18H12ClN3O3S |
Mol. Mass. | 385.824 |
SMILES | OC(=O)Cc1nn(Cc2nc3cccc(Cl)c3s2)c(=O)c2ccccc12 |
Structure |
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