| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin G/H synthase 2 |
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| Ligand | BDBM50260476 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1693913 |
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| IC50 | 1800±n/a nM |
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| Citation |  Zhou, S; Yang, S; Huang, G Design, synthesis and bioactivities of Celecoxib analogues or derivatives. Bioorg Med Chem25:4887-4893 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin G/H synthase 2 |
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| Name: | Prostaglandin G/H synthase 2 |
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| Synonyms: | Cox-2 | Cox2 | Cyclooxygenase | PGH2_RAT | Ptgs2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 69173.51 |
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| Organism: | RAT |
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| Description: | COX-2 0 RAT::P35355 |
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| Residue: | 604 |
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| Sequence: | MLFRAVLLCAALALSHAANPCCSNPCQNRGECMSIGFDQYKCDCTRTGFYGENCTTPEFL
TRIKLLLKPTPNTVHYILTHFKGVWNIVNNIPFLRNSIMRYVLTSRSHLIDSPPTYNVHY
GYKSWEAFSNLSYYTRALPPVADDCPTPMGVKGNKELPDSKEVLEKVLLRREFIPDPQGT
NMMFAFFAQHFTHQFFKTDQKRGPGFTRGLGHGVDLNHVYGETLDRQHKLRLFQDGKLKY
QVIGGEVYPPTVKDTQVDMIYPPHVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCD
ILKQEHPEWDDERLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQ
NRIASEFNTLYHWHPLLPDTFNIEDQEYTFKQFLYNNSILLEHGLAHFVESFTRQIAGRV
AGGRNVPIAVQAVAKASIDQSREMKYQSLNEYRKRFSLKPYTSFEELTGEKEMAAELKAL
YHDIDAMELYPALLVEKPRPDAIFGETMVELGAPFSLKGLMGNPICSPQYWKPSTFGGEV
GFRIINTASIQSLICNNVKGCPFASFNVQDPQPTKTATINASASHSRLDDINPTVLIKRR
STEL
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| BDBM50260476 |
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| n/a |
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| Name | BDBM50260476 |
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| Synonyms: | CHEMBL4093268 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H17F3N4O2S |
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| Mol. Mass. | 386.392 |
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| SMILES | CN1C=CC(C=C1)C1NC(=CN1c1ccc(cc1)S(N)(=O)=O)C(F)(F)F |c:2,5,10| |
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| Structure | 
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