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TargetCyclin-C/Cyclin-dependent kinase 8
LigandBDBM50260927
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1695228 (CHEMBL4046118)
IC50 280±n/a nM
Citation Han, XJiang, MZhou, CZhou, ZXu, ZWang, LMayweg, AVNiu, RJin, TGYang, S Discovery of potent and selective CDK8 inhibitors through FBDD approach. Bioorg Med Chem Lett27:4488-4492 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cyclin-C/Cyclin-dependent kinase 8
Name:Cyclin-C/Cyclin-dependent kinase 8
Synonyms:CDK8/Cyclin C
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of ChEMBL is 1562017
Components:This complex has 2 components.
Component 1
Name:Cyclin-dependent kinase 8
Synonyms:CDK8 | CDK8_HUMAN | Cell division protein kinase 8 | Cyclin-Dependent Kinase 8 (CDK8) | Mediator complex subunit CDK8 | Mediator of RNA polymerase II transcription subunit CDK8 | Protein kinase K35
Type:Serine/threonine-protein kinase
Mol. Mass.:53300.21
Organism:Homo sapiens (Human)
Description:P49336
Residue:464
Sequence:
MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGIS
MSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKP
VQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF
NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED
IKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKH
KVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLT
EEEPDDKGDKKNQQQQQGNNHTNGTGHPGNQDSSHTQGPPLKKVRVVPPTTTSGGLIMTS
DYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQYSHQTHRY
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Component 2
Name:Cyclin-C
Synonyms:CCNC | CCNC_HUMAN | Cyclin C | SRB11 homolog | hSRB11
Type:PROTEIN
Mol. Mass.:33244.88
Organism:Homo sapiens (Human)
Description:ChEMBL_107900
Residue:283
Sequence:
MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQ
VIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRF
SYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIV
NDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQ
WKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS
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BDBM50260927
n/a
NameBDBM50260927
Synonyms:CHEMBL4062035
TypeSmall organic molecule
Emp. Form.C10H7N3
Mol. Mass.169.1827
SMILESN#Cc1cc(c[nH]1)-c1ccncc1
Structure
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