| Reaction Details |
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 | Report a problem with these data |
| Target | Arachidonate 5-lipoxygenase-activating protein |
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| Ligand | BDBM50078033 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1696510 |
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| IC50 | 2.4±n/a nM |
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| Citation |  Bartolozzi, A; Abeywardane, A; Bosanac, T; Broadwater, JA; Chen, Z; Hutzler, JM; Huber, JD; Nemoto, P; Olague, A; Riether, D; Simpson, T; Takahashi, H; Wu, L; Zhang, Y; Zindell, RM Discovery and optimization of oxadiazole-based FLAP inhibitors. Bioorg Med Chem Lett27:4652-4659 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Arachidonate 5-lipoxygenase-activating protein |
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| Name: | Arachidonate 5-lipoxygenase-activating protein |
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| Synonyms: | 5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein |
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| Type: | Enzyme |
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| Mol. Mass.: | 18159.90 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P20292 |
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| Residue: | 161 |
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| Sequence: | MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNC
VDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIIL
FLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
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| BDBM50078033 |
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| n/a |
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| Name | BDBM50078033 |
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| Synonyms: | CHEMBL3417431 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H23N7O2 |
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| Mol. Mass. | 417.4637 |
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| SMILES | COCCn1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(cc1)-c1cnc(N)nc1 |
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| Structure | 
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