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TargetCyclin-K
LigandBDBM50263013
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1697439
IC50 412±n/a nM
Citation Bharate SBKumar VJain SKMintoo MJGuru SKNuthakki VKSharma MBharate SSGandhi SGMondhe DMBhushan SVishwakarma RA Discovery and Preclinical Development of IIIM-290, an Orally Active Potent Cyclin-Dependent Kinase Inhibitor. J Med Chem 61:1664-1687 (2018) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cyclin-K
Name:Cyclin-K
Synonyms:CCNK | CPR4
Type:PROTEIN
Mol. Mass.:64254.10
Organism:Homo sapiens (Human)
Description:ChEMBL_107901
Residue:580
Sequence:
MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDV
GTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTA
RSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQK
LVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQ
DVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPS
QPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIET
THPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRP
PPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPP
NPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGL
PPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50263013
n/a
NameBDBM50263013
Synonyms:CHEMBL4079206
TypeSmall organic molecule
Emp. Form.C23H21Cl2NO5
Mol. Mass.462.323
SMILESCN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(\C=C\c1c(Cl)cccc1Cl)cc2=O |r|
Structure
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