| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50010929 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_54215 |
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| IC50 | 8.8±n/a nM |
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| Citation |  Abraham, A; McGuire, JJ; Galivan, J; Nimec, Z; Kisliuk, RL; Gaumont, Y; Nair, MG Folate analogues. 34. Synthesis and antitumor activity of non-polyglutamylatable inhibitors of dihydrofolate reductase. J Med Chem34:222-7 (1991) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21453.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DHFR. |
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| Residue: | 187 |
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| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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| BDBM50010929 |
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| n/a |
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| Name | BDBM50010929 |
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| Synonyms: | 2-{4-[2-(2,4-Diamino-pteridin-6-yl)-ethyl]-benzoylamino}-4-methylene-pentanedioic acid | CHEMBL307486 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21N7O5 |
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| Mol. Mass. | 451.4353 |
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| SMILES | Nc1nc(N)c2nc(CCc3ccc(cc3)C(=O)NC(CC(=C)C(O)=O)C(O)=O)cnc2n1 |
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| Structure | 
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