Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50010932 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_54215 |
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IC50 | 4.1±n/a nM |
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Citation | Abraham, A; McGuire, JJ; Galivan, J; Nimec, Z; Kisliuk, RL; Gaumont, Y; Nair, MG Folate analogues. 34. Synthesis and antitumor activity of non-polyglutamylatable inhibitors of dihydrofolate reductase. J Med Chem34:222-7 (1991) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 21453.99 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant human DHFR. |
Residue: | 187 |
Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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BDBM50010932 |
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n/a |
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Name | BDBM50010932 |
Synonyms: | (10-DA, 10-Deazaminopterin)2-{4-[2-(2,4-Diamino-pteridin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid | 2-{4-[2-(2,4-Diamino-pteridin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid | 2-{4-[2-(2,4-Diamino-pteridin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid(10-DAM) | CHEMBL11191 |
Type | Small organic molecule |
Emp. Form. | C20H21N7O5 |
Mol. Mass. | 439.4246 |
SMILES | Nc1nc(N)c2nc(CCc3ccc(cc3)C(=O)NC(CCC(O)=O)C(O)=O)cnc2n1 |
Structure |
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