| Reaction Details |
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 | Report a problem with these data |
| Target | Cysteine protease |
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| Ligand | BDBM50263576 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1698165 |
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| Ki | 5.2±n/a nM |
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| Citation |  Giroud, M; Dietzel, U; Anselm, L; Banner, D; Kuglstatter, A; Benz, J; Blanc, JB; Gaufreteau, D; Liu, H; Lin, X; Stich, A; Kuhn, B; Schuler, F; Kaiser, M; Brun, R; Schirmeister, T; Kisker, C; Diederich, F; Haap, W Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors. J Med Chem61:3350-3369 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cysteine protease |
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| Name: | Cysteine protease |
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| Synonyms: | Rhodesain |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48425.78 |
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| Organism: | Trypanosoma brucei rhodesiense |
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| Description: | ChEMBL_619861 |
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| Residue: | 450 |
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| Sequence: | MPRTEMVRFVRLPVVLLAMAACLASVALGSLHVEESLEMRFAAFKKKYGKVYKDAKEEAF
RFRAFEENMEQAKIQAAANPYATFGVTPFSDMTREEFRARYRNGASYFAAAQKRLRKTVN
VTTGRAPAAVDWREKGAVTPVKDQGQCGSCWAFSTIGNIEGQWQVAGNPLVSLSEQMLVS
CDTIDFGCGGGLMDNAFNWIVNSNGGNVFTEASYPYVSGNGEQPQCQMNGHEIGAAITDH
VDLPQDEDAIAAYLAENGPLAIAVDATSFMDYNGGILTSCTSEQLDHGVLLVGYNDSSNP
PYWIIKNSWSNMWGEDGYIRIEKGTNQCLMNQAVSSAVVGGPTPPPPPPPPPSATFTQDF
CEGKGCTKGCSHATFPTGECVQTTGVGSVIATCGASNLTQIIYPLSRSCSGLSVPITVPL
DKCIPILIGSVEYHCSTNPPTKAARLVPHQ
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| BDBM50263576 |
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| n/a |
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| Name | BDBM50263576 |
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| Synonyms: | CHEMBL4072767 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H26ClN5O3 |
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| Mol. Mass. | 515.991 |
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| SMILES | Clc1cc2C[C@H](NC(=O)c3cc(-c4ccccc4)n(CC\C=C\COc1cc2)n3)C(=O)NC1(CC1)C#N |r,t:22| |
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| Structure | 
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