| Reaction Details |
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 | Report a problem with these data |
| Target | Atypical chemokine receptor 3 |
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| Ligand | BDBM50264280 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1698434 (CHEMBL4049324) |
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| Ki | 18±n/a nM |
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| Citation |  Menhaji-Klotz, E; Hesp, KD; Londregan, AT; Kalgutkar, AS; Piotrowski, DW; Boehm, M; Song, K; Ryder, T; Beaumont, K; Jones, RM; Atkinson, K; Brown, JA; Litchfield, J; Xiao, J; Canterbury, DP; Burford, K; Thuma, BA; Limberakis, C; Jiao, W; Bagley, SW; Agarwal, S; Crowell, D; Pazdziorko, S; Ward, J; Price, DA; Clerin, V Discovery of a Novel Small-Molecule Modulator of C-X-C Chemokine Receptor Type 7 as a Treatment for Cardiac Fibrosis. J Med Chem61:3685-3696 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Atypical chemokine receptor 3 |
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| Name: | Atypical chemokine receptor 3 |
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| Synonyms: | ACKR3_MOUSE | Ackr3 | Atypical chemokine receptor 3 | C-X-C chemokine receptor type 7 | CXC-R7 | CXCR-7 | Chemokine orphan receptor 1 | Cmkor1 | Cxcr7 | G-protein coupled receptor RDC1 homolog | RDC-1 | Rdc1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41640.48 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_117401 |
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| Residue: | 362 |
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| Sequence: | MDVHLFDYAEPGNYSDINWPCNSSDCIVVDTVQCPTMPNKNVLLYTLSFIYIFIFVIGMI
ANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVITIPVWVVSLVQHNQWPMGELTCKIT
HLIFSINLFGSIFFLACMSVDRYLSITYFTGTSSYKKKMVRRVVCILVWLLAFFVSLPDT
YYLKTVTSASNNETYCRSFYPEHSIKEWLIGMELVSVILGFAVPFTIIAIFYFLLARAMS
ASGDQEKHSSRKIIFSYVVVFLVCWLPYHFVVLLDIFSILHYIPFTCQLENVLFTALHVT
QCLSLVHCCVNPVLYSFINRNYRYELMKAFIFKYSAKTGLTKLIDASRVSETEYSALEQN
TK
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| BDBM50264280 |
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| n/a |
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| Name | BDBM50264280 |
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| Synonyms: | CHEMBL4084050 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H42N6O3 |
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| Mol. Mass. | 522.6822 |
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| SMILES | [H][C@@]12CC[C@@]([H])(O1)[C@H](C2)C(=O)N1CCC(CC1)[C@H](CC(N)=O)N1CCCN(CC1)c1c(CC)ccn2ccnc12 |r| |
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| Structure | 
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