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TargetRAF serine/threonine protein kinase
LigandBDBM50264717
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1699091
IC50 47±n/a nM
Citation Wang LZhang QZhu GZhang ZZhi YZhang LMao TZhou XChen YLu TTang W Design, synthesis and evaluation of derivatives based on pyrimidine scaffold as potent Pan-Raf inhibitors to overcome resistance. Eur J Med Chem 130:86-106 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
RAF serine/threonine protein kinase
Name:RAF serine/threonine protein kinase
Synonyms:ARAF | ARAF1 | PKS | PKS2 | Proto-oncogene A-Raf | Proto-oncogene A-Raf-1 | Proto-oncogene Pks
Type:Enzyme
Mol. Mass.:67610.81
Organism:Homo sapiens (Human)
Description:P10398
Residue:606
Sequence:
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPSNRPLNELL
TPQGPSPRTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFS
TDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP
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  Blast E-value cutoff:
BDBM50264717
n/a
NameBDBM50264717
Synonyms:CHEMBL4082425
TypeSmall organic molecule
Emp. Form.C29H30ClF3N6O2
Mol. Mass.587.036
SMILESCc1ccc(cc1NC(=O)C1(CC1)c1cc(NCCN2CCCC2)ncn1)C(=O)Nc1ccc(Cl)c(c1)C(F)(F)F
Structure
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