Reaction Details |
| Report a problem with these data |
Target | Serine/threonine-protein kinase A-Raf |
---|
Ligand | BDBM50264731 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1699091 (CHEMBL4050073) |
---|
IC50 | 57±n/a nM |
---|
Citation | Wang, L; Zhang, Q; Zhu, G; Zhang, Z; Zhi, Y; Zhang, L; Mao, T; Zhou, X; Chen, Y; Lu, T; Tang, W Design, synthesis and evaluation of derivatives based on pyrimidine scaffold as potent Pan-Raf inhibitors to overcome resistance. Eur J Med Chem130:86-106 (2017) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Serine/threonine-protein kinase A-Raf |
---|
Name: | Serine/threonine-protein kinase A-Raf |
Synonyms: | ARAF | ARAF1 | ARAF_HUMAN | PKS | PKS2 | Proto-oncogene A-Raf | Proto-oncogene A-Raf-1 | Proto-oncogene Pks | RAF serine/threonine protein kinase |
Type: | Enzyme |
Mol. Mass.: | 67610.81 |
Organism: | Homo sapiens (Human) |
Description: | P10398 |
Residue: | 606 |
Sequence: | MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPSNRPLNELL
TPQGPSPRTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFS
TDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP
|
|
|
BDBM50264731 |
---|
n/a |
---|
Name | BDBM50264731 |
Synonyms: | CHEMBL4060531 |
Type | Small organic molecule |
Emp. Form. | C30H32ClF3N6O2 |
Mol. Mass. | 601.062 |
SMILES | Cc1ccc(cc1NC(=O)C1(CC1)c1cc(NCCN2CCCCC2)ncn1)C(=O)Nc1ccc(Cl)c(c1)C(F)(F)F |
Structure |
|