| Reaction Details |
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 | Report a problem with these data |
| Target | Kynurenine 3-monooxygenase |
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| Ligand | BDBM50266088 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1700449 (CHEMBL4051431) |
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| IC50 | 3.2±n/a nM |
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| Citation |  Walker, AL; Ancellin, N; Beaufils, B; Bergeal, M; Binnie, M; Bouillot, A; Clapham, D; Denis, A; Haslam, CP; Holmes, DS; Hutchinson, JP; Liddle, J; McBride, A; Mirguet, O; Mowat, CG; Rowland, P; Tiberghien, N; Trottet, L; Uings, I; Webster, SP; Zheng, X; Mole, DJ Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis. J Med Chem60:3383-3404 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kynurenine 3-monooxygenase |
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| Name: | Kynurenine 3-monooxygenase |
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| Synonyms: | KMO | KMO_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 55831.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1487479 |
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| Residue: | 486 |
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| Sequence: | MDSSVIQRKKVAVIGGGLVGSLQACFLAKRNFQIDVYEAREDTRVATFTRGRSINLALSH
RGRQALKAVGLEDQIVSQGIPMRARMIHSLSGKKSAIPYGTKSQYILSVSRENLNKDLLT
AAEKYPNVKMHFNHRLLKCNPEEGMITVLGSDKVPKDVTCDLIVGCDGAYSTVRSHLMKK
PRFDYSQQYIPHGYMELTIPPKNGDYAMEPNYLHIWPRNTFMMIALPNMNKSFTCTLFMP
FEEFEKLLTSNDVVDFFQKYFPDAIPLIGEKLLVQDFFLLPAQPMISVKCSSFHFKSHCV
LLGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLS
MYNYIEMRAHVNSSWFIFQKNMERFLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKK
VINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIAHFRNTTCFPAKAVDSLEQI
SNLISR
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| BDBM50266088 |
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| n/a |
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| Name | BDBM50266088 |
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| Synonyms: | CHEMBL4086792 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H25Cl2N3O8 |
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| Mol. Mass. | 518.345 |
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| SMILES | NC(CO)(CO)CO.C[C@@H](Oc1cc2oc(=O)n(CCC(O)=O)c2cc1Cl)c1ccc(Cl)cn1 |r| |
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| Structure | 
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