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TargetLysyl oxidase homolog 2
LigandBDBM50266821
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1701350 (CHEMBL4052332)
IC50 160±n/a nM
Citation Rowbottom, MWBain, GCalderon, ILasof, TLonergan, DLai, AHuang, FDarlington, JProdanovich, PSantini, AMKing, CDGoulet, LShannon, KEMa, GLNguyen, KMacKenna, DAEvans, JFHutchinson, JH Identification of 4-(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2). J Med Chem60:4403-4423 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Lysyl oxidase homolog 2
Name:Lysyl oxidase homolog 2
Synonyms:1.4.3.13 | LOXL2 | LOXL2_HUMAN | Lysyl oxidase homolog 2 | Lysyl oxidase-like protein 2 | Lysyl oxidase-related protein 2 | Lysyl oxidase-related protein WS9-14
Type:PROTEIN
Mol. Mass.:86721.38
Organism:Homo sapiens (Human)
Description:ChEMBL_115990
Residue:774
Sequence:
MERPLCSHLCSCLAMLALLSPLSLAQYDSWPHYPEYFQQPAPEYHQPQAPANVAKIQLRL
AGQKRKHSEGRVEVYYDGQWGTVCDDDFSIHAAHVVCRELGYVEAKSWTASSSYGKGEGP
IWLDNLHCTGNEATLAACTSNGWGVTDCKHTEDVGVVCSDKRIPGFKFDNSLINQIENLN
IQVEDIRIRAILSTYRKRTPVMEGYVEVKEGKTWKQICDKHWTAKNSRVVCGMFGFPGER
TYNTKVYKMFASRRKQRYWPFSMDCTGTEAHISSCKLGPQVSLDPMKNVTCENGLPAVVS
CVPGQVFSPDGPSRFRKAYKPEQPLVRLRGGAYIGEGRVEVLKNGEWGTVCDDKWDLVSA
SVVCRELGFGSAKEAVTGSRLGQGIGPIHLNEIQCTGNEKSIIDCKFNAESQGCNHEEDA
GVRCNTPAMGLQKKLRLNGGRNPYEGRVEVLVERNGSLVWGMVCGQNWGIVEAMVVCRQL
GLGFASNAFQETWYWHGDVNSNKVVMSGVKCSGTELSLAHCRHDGEDVACPQGGVQYGAG
VACSETAPDLVLNAEMVQQTTYLEDRPMFMLQCAMEENCLSASAAQTDPTTGYRRLLRFS
SQIHNNGQSDFRPKNGRHAWIWHDCHRHYHSMEVFTHYDLLNLNGTKVAEGHKASFCLED
TECEGDIQKNYECANFGDQGITMGCWDMYRHDIDCQWVDITDVPPGDYLFQVVINPNFEV
AESDYSNNIMKCRSRYDGHRIWMYNCHIGGSFSEETEKKFEHFSGLLNNQLSPQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50266821
n/a
NameBDBM50266821
Synonyms:CHEMBL4087273 | US11072585, Example 34
TypeSmall organic molecule
Emp. Form.C19H21F3N4O2
Mol. Mass.394.3908
SMILESNCc1cc(O[C@H]2CCCN(C2)C(=O)Nc2ccccc2)nc(c1)C(F)(F)F |r|
Structure
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