| Reaction Details |
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 | Report a problem with these data |
| Target | Lysyl oxidase homolog 2 |
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| Ligand | BDBM50266826 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1701350 (CHEMBL4052332) |
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| IC50 | 140±n/a nM |
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| Citation |  Rowbottom, MW; Bain, G; Calderon, I; Lasof, T; Lonergan, D; Lai, A; Huang, F; Darlington, J; Prodanovich, P; Santini, AM; King, CD; Goulet, L; Shannon, KE; Ma, GL; Nguyen, K; MacKenna, DA; Evans, JF; Hutchinson, JH Identification of 4-(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2). J Med Chem60:4403-4423 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysyl oxidase homolog 2 |
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| Name: | Lysyl oxidase homolog 2 |
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| Synonyms: | 1.4.3.13 | LOXL2 | LOXL2_HUMAN | Lysyl oxidase homolog 2 | Lysyl oxidase-like protein 2 | Lysyl oxidase-related protein 2 | Lysyl oxidase-related protein WS9-14 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 86721.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_115990 |
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| Residue: | 774 |
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| Sequence: | MERPLCSHLCSCLAMLALLSPLSLAQYDSWPHYPEYFQQPAPEYHQPQAPANVAKIQLRL
AGQKRKHSEGRVEVYYDGQWGTVCDDDFSIHAAHVVCRELGYVEAKSWTASSSYGKGEGP
IWLDNLHCTGNEATLAACTSNGWGVTDCKHTEDVGVVCSDKRIPGFKFDNSLINQIENLN
IQVEDIRIRAILSTYRKRTPVMEGYVEVKEGKTWKQICDKHWTAKNSRVVCGMFGFPGER
TYNTKVYKMFASRRKQRYWPFSMDCTGTEAHISSCKLGPQVSLDPMKNVTCENGLPAVVS
CVPGQVFSPDGPSRFRKAYKPEQPLVRLRGGAYIGEGRVEVLKNGEWGTVCDDKWDLVSA
SVVCRELGFGSAKEAVTGSRLGQGIGPIHLNEIQCTGNEKSIIDCKFNAESQGCNHEEDA
GVRCNTPAMGLQKKLRLNGGRNPYEGRVEVLVERNGSLVWGMVCGQNWGIVEAMVVCRQL
GLGFASNAFQETWYWHGDVNSNKVVMSGVKCSGTELSLAHCRHDGEDVACPQGGVQYGAG
VACSETAPDLVLNAEMVQQTTYLEDRPMFMLQCAMEENCLSASAAQTDPTTGYRRLLRFS
SQIHNNGQSDFRPKNGRHAWIWHDCHRHYHSMEVFTHYDLLNLNGTKVAEGHKASFCLED
TECEGDIQKNYECANFGDQGITMGCWDMYRHDIDCQWVDITDVPPGDYLFQVVINPNFEV
AESDYSNNIMKCRSRYDGHRIWMYNCHIGGSFSEETEKKFEHFSGLLNNQLSPQ
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| BDBM50266826 |
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| n/a |
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| Name | BDBM50266826 |
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| Synonyms: | CHEMBL4105137 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H15ClF3N3O3 |
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| Mol. Mass. | 377.746 |
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| SMILES | Cl.CONC(=O)c1cccc(Oc2cc(CN)cc(n2)C(F)(F)F)c1 |
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| Structure | 
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