Reaction Details | |||
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Target | Protein Mdm4 | ||
Ligand | BDBM50266878 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1701466 (CHEMBL4052448) | ||
Ki | 3150±n/a nM | ||
Citation | Twarda-Clapa, A; Krzanik, S; Kubica, K; Guzik, K; Labuzek, B; Neochoritis, CG; Khoury, K; Kowalska, K; Czub, M; Dubin, G; Dömling, A; Skalniak, L; Holak, TA 1,4,5-Trisubstituted Imidazole-Based p53-MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers. J Med Chem60:4234-4244 (2017) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Protein Mdm4 | |||
Name: | Protein Mdm4 | ||
Synonyms: | Double minute 4 protein | Double minute 4 protein (HDM4) | MDM2-MDMX | MDM4 | MDM4_HUMAN | MDMX | Mdm2-like p53-binding protein | Protein Mdm4 | Protein Mdmx | p53-Binding Protein HDMX | p53-binding protein | p53-binding protein Mdm4 | ||
Type: | Oncoprotein | ||
Mol. Mass.: | 54842.04 | ||
Organism: | Homo sapiens (Human) | ||
Description: | The HDMX(1-188) were expressed in Escherichia coli BL21 (DE3) as a GST fusion and purified on glutathione sepharose. | ||
Residue: | 490 | ||
Sequence: |
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BDBM50266878 | |||
n/a | |||
Name | BDBM50266878 | ||
Synonyms: | CHEMBL4078749 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H16Cl2FN3O2 | ||
Mol. Mass. | 480.318 | ||
SMILES | OC(=O)c1[nH]c2cc(Cl)ccc2c1-c1c(ncn1Cc1ccc(Cl)cc1)-c1ccc(F)cc1 |(14.91,-19.06,;15.68,-20.39,;14.91,-21.72,;17.22,-20.39,;18.12,-21.64,;19.59,-21.16,;20.92,-21.93,;22.25,-21.16,;23.59,-21.93,;22.25,-19.62,;20.92,-18.85,;19.59,-19.62,;18.12,-19.15,;17.64,-17.68,;18.56,-16.44,;17.64,-15.19,;16.19,-15.67,;16.19,-17.21,;14.94,-18.11,;13.53,-17.48,;12.28,-18.39,;10.88,-17.77,;10.72,-16.23,;9.31,-15.61,;11.96,-15.33,;13.37,-15.96,;20.1,-16.44,;20.86,-17.78,;22.4,-17.78,;23.17,-16.44,;24.71,-16.44,;22.39,-15.1,;20.85,-15.11,)| | ||
Structure |