| Reaction Details |
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 | Report a problem with these data |
| Target | Platelet-activating factor receptor |
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| Ligand | BDBM50011612 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_56498 |
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| IC50 | 6±n/a nM |
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| Citation |  Walser, A; Flynn, T; Mason, C; Crowley, H; Maresca, C; Yaremko, B; O'Donnell, M Triazolobenzo- and triazolothienodiazepines as potent antagonists of platelet activating factor. J Med Chem34:1209-21 (1991) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Platelet-activating factor receptor |
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| Name: | Platelet-activating factor receptor |
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| Synonyms: | PAF Platelet activating factor | PAF-R | PAFR | PTAFR | PTAFR_HUMAN | Platelet activating factor receptor | Platelet-activating factor receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 39219.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | PAF Platelet activating factor PTAFR HUMAN::P25105 |
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| Residue: | 342 |
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| Sequence: | MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLT
MADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVT
RPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKG
SVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAV
FIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKF
RKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN
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| BDBM50011612 |
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| n/a |
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| Name | BDBM50011612 |
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| Synonyms: | 1-{3-[6-(2-Fluoro-phenyl)-1,4-dimethyl-4H-2,3,5,10b-tetraaza-benzo[e]azulen-8-yl]-prop-2-ynyl}-3,4-dihydro-1H-quinolin-2-one | CHEMBL277246 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H24FN5O |
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| Mol. Mass. | 489.5429 |
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| SMILES | C[C@@H]1N=C(c2ccccc2F)c2cc(ccc2-n2c(C)nnc12)C#CCN1C(=O)CCc2ccccc12 |t:2| |
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| Structure | 
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